RT Journal Article
T1 microRNA Fine-Tuning of the Germinal Center Response
A1 Fuertes, Teresa
A1 Salgado, Irene
A1 García-Yébenes Mena, Virginia Pilar
AB Germinal centers (GCs) are complex multicellular structures in which antigen-specific B cells undergo the molecular remodeling that enables the generation of high-affinity antibodies and the differentiation programs that lead to the generation of plasma-antibody-secreting cells and memory B cells. These reactions are tightly controlled by a variety of mechanisms, including the post-transcriptional control of gene expression by microRNAs (miRNAs). Through the development of animal models with B cell-specific modified miRNA expression, we have contributed to the understanding of the role of miRNAs in the regulation of GC responses and in B cell neoplasia. Here, we review recent advances in the understanding of the role of miRNAs in the regulation of B cell and T follicular helper physiology during the GC response and in the diseases associated to GC response dysregulation.
PB Frontiers Media
SN 1664-3224
YR 2021
FD 2021-04-19
LK https://hdl.handle.net/20.500.14352/91954
UL https://hdl.handle.net/20.500.14352/91954
LA eng
NO Fuertes T, Salgado I, de Yébenes VG. microRNA Fine-Tuning of the Germinal Center Response. Front Immunol. 2021 Apr 19;12:660450. doi: 10.3389/fimmu.2021.660450. PMID: 33953721; PMCID: PMC8089396
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 16 abr 2025