RT Journal Article
T1 Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016-2022
A1 Miguel Díez, Javier De
A1 López De Andrés, Ana Isabel
A1 Zamorano León, José Javier
A1 Hernández Barrera, Valentín
A1 Cuadrado Corrales, María Natividad
A1 Jiménez Sierra, Ana
A1 Carabantes Alarcón, David
A1 Jiménez García, Rodrigo
AB bjectives: To analyze the number and clinical characteristics of hospital admissions in Spain between 2016 and 2022 in which alpha-1-antitrypsin deficiency (AATD) was coded; to describe and analyze differences in these parameters between men and women; and to identify variables associated with a worse prognosis. Methods: We used a nationwide discharge database to select all admissions featuring an AATD diagnostic code (ICD-10 code E88.01) in any position. Results: We found 5142 hospital admissions with a diagnosis of AATD and detected a significant increase in their number from 2016 to 2022 (p = 0.034 for trend). Males accounted for 58.21% of the hospitalizations and had a higher Charlson Comorbidity Index than women (1.86 vs. 1.33; p < 0.001), were hospitalized more frequently (21.18% of men were hospitalized more than once vs. 17.76% of women, p < 0.001), and had a higher probability of severe disease (OR 1.39; 95%CI 1.10-1.75). Crude in-hospital mortality (IHM) was 6.85% in men and 4.8% in women (p = 0.007). The variables associated with IHM in both sexes were older age, more hospital admissions, and liver disease or lung cancer. Invasive and non-invasive mechanical ventilation and admission to the ICU were also associated with IHM in men and women. Multivariable adjustment revealed no association between sex and IHM. Conclusions: The number of hospitalizations for AATD increased in Spain from 2016 to 2022. Men represented almost 60% of hospitalizations, were admitted more frequently and with more comorbidities, and had a higher probability of severe disease than women. There was no association between sex and IHM.
PB MDPI
YR 2024
FD 2024-09-22
LK https://hdl.handle.net/20.500.14352/117898
UL https://hdl.handle.net/20.500.14352/117898
LA eng
NO de-Miguel-Diez, J., Lopez-de-Andres, A., Zamorano-Leon, J. J., Hernández-Barrera, V., Cuadrado-Corrales, N., Jimenez-Sierra, A., Carabantes-Alarcon, D., & Jimenez-Garcia, R. (2024). Hospital Admission Trends in Alpha-1-Antitrypsin Deficiency: A Sex-Based Analysis from the Spanish National Discharge Database, 2016–2022. Journal of Clinical Medicine, 13(21), 6564. https://doi.org/10.3390/jcm13216564
NO Comunidad Autónoma de Madrid
NO Universidad Complutense de Madrid
NO Sociedad Española de Neumología y Cirugía de Tórax
NO Sociedad Madrileña de Neumología y Cirugía de Tórax
DS Docta Complutense
RD 4 abr 2025