RT Journal Article
T1 Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion
A1 Corrochano, Alberto R
A1 Arranz Gutiérrez, Elena María
A1 De Noni, Ivano
A1 Stuknytè, Milda
A1 Ferraretto, Anita
A1 Kelly, Phil M
A1 Buckin, Vitaly
A1 Giblin, Linda
AB Bovine whey proteins are widely incorporated in foods for their nutritional, health promoting and functional value. However, whey proteins are readily digested in the upper gut. The objective of this study was to determine the fate and bioactivity of bovine whey proteins post simulated gastrointestinal digestion (GID). Our results demonstrated that β-lactoglobulin and α-lactalbumin post GID protect human intestinal cells from free radical formation. Post GID, lactoferrin significantly increased the amount of the intracellular antioxidant enzymes superoxide dismutase 1, 2 and thioredoxin. In addition, all whey samples post GID inhibited the activity of the dipeptidyl peptidase IV. However, the conditions of the gut destroyed the ability of whey proteins to act as glucagon-like peptide-1 secretagogues. The peptide profiles of GID whey protein isolate, β-lactoglobulin, α-lactalbumin, bovine serum albumin and lactoferrin revealed several peptides with bioactive potential.
PB Elsevier
SN 1756-4646
YR 2018
FD 2018-09-24
LK https://hdl.handle.net/20.500.14352/93603
UL https://hdl.handle.net/20.500.14352/93603
LA eng
NO Corrochano, A. R., Arranz, E., De Noni, I., Stuknytė, M., Ferraretto, A., Kelly, P. M., ... & Giblin, L. (2018). Intestinal health benefits of bovine whey proteins after simulated gastrointestinal digestion. Journal of Functional Foods, 49, 526-535
NO Department of Agriculture, Food and the Marine
NO Department of Agriculture, Food and the Marine (Dublin, Ireland)
DS Docta Complutense
RD 6 abr 2025