RT Journal Article
T1 Beta-lactam antibiotics modify root architecture and indole glucosinolate metabolism in Arabidopsis thaliana
A1 Gudiño-Gomezjurado, Marco
A1 Blanco-Touriño, Noel
A1 Arbona, Vicent
A1 Gómez-Cadenas, Aurelio
A1 Blázquez, Miguel Ángel
A1 Navarro García, Federico
AB The presence of antibiotics in soils could be due to natural production by soil microorganisms or to the effect of anthropogenic activities. However, the impact of these compounds on plant physiology has not been thoroughly investigated. To evaluate the effect of b-lactam antibiotics (carbenicillin and penicillin) on the growth and development of Arabidopsis thaliana roots, plants were grown in the presence of different amounts and we found a reduction in root size, an increase in the size of root hairs as well as an abnormal position closer to the tip of the roots. Those phenomena were dependent on the accumulation of both antibiotics inside root tissues and also correlated with a decrease in size of the root apical meristem not related to an alteration in cell division but to a decrease in cell expansion.Using an RNA sequencing analysis, we detected an increase in the expression of genes related to the response to oxidative stress, which would explain the increase in the levels of endogenous reactive oxygen species found in the presence of those antibiotics. Moreover, some auxin-responsive genes were misregulated, especially an induction of CYP79B3, possiblyexplaining the increase in auxin levels in the presence of carbenicillin and the decrease in the amount of indole glucosinolates, involved in the control of fungal infections. Accordingly, penicillin-treated plants were hypersensitive to the endophyte fungus Colletotrichum tofieldiae. These results underscore the risks for plant growth of b-lactam antibiotics in agricultural soils, and suggest a possible function for these compounds as fungus-produced signaling molecules to modify plant behavior.
PB Oxford University Press
YR 2018
FD 2018-07-03
LK https://hdl.handle.net/20.500.14352/125885
UL https://hdl.handle.net/20.500.14352/125885
LA eng
NO Gudiño ME, Blanco-Touriñán N, Arbona V, Gómez-Cadenas A, Blázquez MA, Navarro-García F. Β-lactam antibiotics modify root architecture and indole glucosinolate metabolism in arabidopsis thaliana. Plant and Cell Physiology [Internet]. 1 de octubre de 2018 [citado 7 de noviembre de 2025];59(10):2086-98. Disponible en: https://academic.oup.com/pcp/article/59/10/2086/5050038
NO Ministerio de Medio Ambiente Rural y Marino
NO Ministerio de Economía y Competitividad
NO Secretaría Nacional de Educación Superior Ciencia y Tecnologia (SENESCYT) (Ecuador)
DS Docta Complutense
RD 30 dic 2025