RT Journal Article
T1 The Role of Autophagy in Eye Diseases
A1 Fernández Albarral, José A.
A1 de Julián López, Esther
A1 Soler Domínguez, Carmen
A1 de Hoz, Rosa
A1 López Cuenca, Inés
A1 Salobrar García, Elena
A1 Ramírez Sebastián, José Manuel
A1 Pinazo Durán, María D.
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, Ana Isabel
AB Autophagy is a catabolic process that ensures homeostasis in the cells of our organism. It plays a crucial role in protecting eye cells against oxidative damage and external stress factors. Ocular pathologies of high incidence, such as age-related macular degeneration, cataracts, glaucoma, and diabetic retinopathy are of multifactorial origin and are associated with genetic, environmental factors, age, and oxidative stress, among others; the latter factor is one of the most influential in ocular diseases, directly affecting the processes of autophagy activity. Alteration of the normal functioning of autophagy processes can interrupt organelle turnover, leading to the accumulation of cellular debris and causing physiological dysfunction of the eye. The aim of this study is to review research on the role of autophagy processes in the main ocular pathologies, which have a high incidence and result in high costs for the health system. Considering the role of autophagy processes in cell homeostasis and cell viability, the control and modulation of autophagy processes in ocular pathologies could constitute a new therapeutic approach.
PB MDPI
SN 2075-1729
YR 2021
FD 2021
LK https://hdl.handle.net/20.500.14352/7389
UL https://hdl.handle.net/20.500.14352/7389
LA eng
NO This research was funded by the Ophthalmological Network OFTARED (Enfermedades oculares: Prevención, detección precoz, tratamiento y rehabilitación de las patologías oculares) (RD16/0008/0005 and RD16/0008/0026) of the Institute of Health of Carlos III of the Spanish Ministry of Economy and by the European programme FEDER; and Network RETiBRAIN (La retina un modelo para investigar Neuroprotección en patologías del Sistema Nervioso Central) (RED2018-102499-T) of Spanish Ministry of Science and Innovation. And J.A.F.-A. is currently funded by a Predoctoral Fellowship (FPU17/01023) from the Spanish Ministry of Science, Innovation, and Universities; and I.L.-C. is currently funded by a Predoctoral Fellowship (CT42/18-CT43/18) from the Complutense University of Madrid.
NO Unión Europea
NO Ministerio de Ciencia e Innovación (España)
NO Instituto de Salud Carlos III
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 3 may 2024