RT Journal Article
T1 Oxidative stress increases in liver of lactating rats after BPF-low-dose exposure: perinatal effects in the offspring
A1 Linillos Pradillo, Beatriz
A1 Rancán, Lisa
A1 García Murias, Julio
A1 Margret Schlumpf, 
A1 Walter Lichtensteiger, 
A1 Fernández-Tresguerres Hernández, Jesús Ángel
A1 Vara Ameigeiras, Elena María
A1 Paredes Royano, Sergio Damián
AB Bisphenol F (BPF) is replacing Bisphenol A (BPA) in the manufacture of products due to endocrine-disrupting effects. BPF monomers can also be released into the environment and enter the food chain, resulting in human exposure to low doses. Since bisphenols are primarily metabolized by the liver, this organ is more vulnerable to lower doses of bisphenols than others. Exposure during prenatal development may increase the risk of diseases in adulthood. The aim was to evaluate whether BPF administration could generate oxidative stress in liver of lactating rats, and whether these effects may be also observed in female and male postnatal day 6 (PND6) offspring. Long Evans rats received oral treatment: Control, BPF-low-dose (LBPF) 0.0365 mg/kg b.w./day, and BPF-high-dose (HBPF) 3.65 mg/kg b.w./day. The levels of antioxidant enzymes (CAT, SOD, GR, GPx and GST), glutathione system (GSH, GSSG) and lipid damage markers (MDA, LPO) were measured using colorimetric methods in liver of both lactating dams and in PND6 offspring. Mean values were analyzed using Prism-7. LBPF affected liver defense mechanisms (antioxidant enzymes and glutathione system), increasing ROS levels and producing lipid peroxidation in lactating dams. Similar effects were found in female and male PND6 offspring as a consequence of perinatal exposure.
SN 2045-2322
YR 2023
FD 2023-07-11
LK https://hdl.handle.net/20.500.14352/114316
UL https://hdl.handle.net/20.500.14352/114316
LA eng
NO Linillos-Pradillo B, Rancan L, Murias JG, Schlumpf M, Lichtensteiger W, Tresguerres JAF, Vara E, Paredes SD. Oxidative stress increases in liver of lactating rats after BPF-low-dose exposure: perinatal effects in the offspring. Sci Rep. 2023 Jul 11;13(1):11229. doi: 10.1038/s41598-023-38434-w. PMID: 37433837; PMCID: PMC10336036.
DS Docta Complutense
RD 6 abr 2025