RT Journal Article
T1 Magnetic colloidal nanoformulations to remotely trigger mechanotransduction for osteogenic differentiation
A1 Gutiérrez Estévez, Manuel
A1 Cicuéndez Maroto, Mónica
A1 Colilla Nieto, Montserrat
A1 Vallet Regí, María Dulce Nombre
A1 González Ortiz, Blanca
A1 Izquierdo Barba, Isabel
AB Nowadays, diseases associated with an ageing population, such as osteoporosis, require the development of new biomedical approaches to bone regeneration. In this regard, mechanotransduction has emerged as a discipline within the field of bone tissue engineering. Herein, we have tested the efficacy of superparamagnetic iron oxide nanoparticles (SPIONs), obtained by the thermal decomposition method, with an average size of 13 nm, whenexposed to the application of an external magnetic field for mechanotransduction in human bone marrowderived mesenchymal stem cells (hBM-MSCs). The SPIONs were functionalized with an Arg-Gly-Asp (RGD) peptide as ligand to target integrin receptors on cell membrane and used in colloidal state. Then, a comprehensive and comparative bioanalytical characterization of non-targeted versus targeted SPIONs was performed interms of biocompatibility, cell uptake pathways and mechanotransduction effect, demonstrating the osteogenic
YR 2024
FD 2024-03-14
LK https://hdl.handle.net/20.500.14352/102901
UL https://hdl.handle.net/20.500.14352/102901
LA eng
NO European Union’s Horizon 2020
NO Ministerio de Ciencia e Innovación
DS Docta Complutense
RD 6 abr 2025