RT Journal Article
T1 Infralimbic cortex controls the activity of the hypothalamus-pituitary adrenal axis and the formation of aversive memory: effects of environmental enrichment
A1 Ronzoni, Giacomo
A1 Antón, María
A1 Mora Teruel, Francisco
A1 Segovia Camargo, Gregorio
A1 Arco González, Alberto Del
AB The aim of the present study was to investigate the effects of the stimulation and inhibition of the ventral part of the medial prefrontal cortex (infralimbic cortex) on basal and stress-induced plasma levels of corticosterone and on the acquisition of aversive memory in animals maintained in control and environmental enrichment (EE) conditions. Intracortical microinjections of the GABAA antagonist picrotoxin and agonist muscimol were performed in male Wistar rats to stimulate and inhibit, respectively, the activity of the infralimbic cortex. Injections were performed 60 min before foot shock stress and training in the inhibitory avoidance task. Picrotoxin injections into the infralimbic cortex increased basal plasma levels of corticosterone. These increases were higher in EE rats which suggest that EE enhances the control exerted by infralimbic cortex over the hypothalamus-pituitary-adrenal (HPA) axis and corticosterone release. Muscimol injections into the infralimbic cortex reduced the stress-induced plasma levels of corticosterone and the retention latency 24 h after training in the inhibitory avoidance performance in control and EE animals, respectively. These results further suggest that the infralimbic cortex is required for the activation of the HPA axis during stress and for the acquisition of contextual aversive memories.
PB Elsevier
SN 0166-4328
YR 2016
FD 2016-01
LK https://hdl.handle.net/20.500.14352/24698
UL https://hdl.handle.net/20.500.14352/24698
LA eng
NO Ministerio de Educación y Ciencia (MEC)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 7 abr 2025