RT Journal Article
T1 The Role of Tumor Microenvironment in Multiple Myeloma Development and Progression
A1 García Ortiz, Almudena
A1 Rodríguez García, Yaiza
A1 Encinas, Jessica
A1 Maroto Martín, Elena
A1 Castellano, Eva
A1 Teixidó, Joaquín
A1 Martínez López, Joaquín
AB Multiple myeloma (MM) is a hematologic cancer characterized by clonal proliferation of plasma cells in the bone marrow (BM). The progression, from the early stages of the disease as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM) to MM and occasionally extramedullary disease, is drastically affected by the tumor microenvironment (TME). Soluble factors and direct cell–cell interactions regulate MM plasma cell trafficking and homing to the BM niche. Mesenchymal stromal cells, osteoclasts, osteoblasts, myeloid and lymphoid cells present in the BM create a unique milieu that favors MM plasma cell immune evasion and promotes disease progression. Moreover, TME is implicated in malignant cell protection against anti-tumor therapy. This review describes the main cellular and non-cellular components located in the BM, which condition the immunosuppressive environment and lead the MM establishment and progression.
PB MPDI
SN 2072-6694
YR 2021
FD 2021-01-09
LK https://hdl.handle.net/20.500.14352/6884
UL https://hdl.handle.net/20.500.14352/6884
LA eng
NO Ministerio de Ciencia e Innovación (MICINN)
NO Instituto de Salud Carlos III/ CRIS Foundation
NO Instituto de Salud Carlos III (ISCIII)
NO Research Institute Hospital 12 de Octubre
DS Docta Complutense
RD 9 abr 2025