RT Journal Article
T1 Membrane peroxidation index and maximum lifespan are negatively correlated in fish of the genus Nothobranchius
A1 Costa Ruiz, Jorge de
A1 Barja de Quiroga, Gustavo
A1 Almaida-Pagan, Pedro F.
AB The lipid composition of cell membranes is linked to metabolic rate and lifespan in mammals and birds but very little information is available for fish. In this study, three fish species of the short-lived annual genus Nothobranchius with different maximum lifespan potential (MLSP) and the longer-lived outgroup species Aphyosemion australe were studied to test whether they conform to the predictions of the longevity– homeoviscous adaptation (LHA) theory of ageing. Lipid analyses were performed in whole-fish samples and the peroxidation index (PIn) for every phospholipid (PL) class and for the whole membrane was calculated. Total PL content was significantly lower in A. australe and N. korthausae, the two species with the highest MLSP, and a negative correlation between membrane total PIn and fish MLSP was found, meaning that the longer-lived fish species have more saturated membranes and, therefore, a lower susceptibility to oxidative damage, as the LHA theory posits.
PB The Company of Biologists
SN 0022-0949, 1477-9145
YR 2020
FD 2020-06-04
LK https://hdl.handle.net/20.500.14352/6591
UL https://hdl.handle.net/20.500.14352/6591
LA eng
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
NO Ministerio de Ciencia e Innovación (MICINN)/FEDER
NO Instituto de Salud Carlos III
NO Fundación Séneca
NO Fundación ONCE/Fondo Social Europeo
DS Docta Complutense
RD 6 abr 2025