%0 Journal Article
%A Vargas Balbuena, Javier
%A Gómez Pedrero, José Antonio
%A Quiroga Mellado, Juan Antonio
%A Alonso Fernández, José
%T Enhancement of Cryo-EM maps by a multiscale tubular filter
%D 2022
%@ 1094-4087
%U https://hdl.handle.net/20.500.14352/71328
%X We present an approach to enhance cryo-electron microscopy (cryo-EM) postprocessed maps based on a multiscale tubular filter. The method determines a tubularness measure locally by the analysis of the eigenvalues of the Hessian matrix. This information is used to enhance elongated local structures and to attenuate blob-like and plate-like structures. The approach, thus, introduces a priori information in the reconstructions to improve their interpretability and analysis at high-resolution. The proposed method has been tested with simulated and real cryo-EM maps including recent reconstructions of the SARS-CoV-2. Our results show that our methods can improve obtained reconstructions.
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