RT Journal Article
T1 Early Measurement of Indocyanine Green Clearance Accurately Predicts Short-Term Outcomes After Liver Transplantation
T2 
A1 Olmedilla, Luis
A1 Lisbona, Cristina J.
A1 Pérez Peña, José M.
A1 López Baena, José Ángel
A1 Garutti Martínez, Ignacio
A1 Salcedo Plaza, María Magdalena
A1 Sanz, Javier
A1 Tisner, Manuel
A1 Asencio Pascual, José Manuel
A1 Fernández Quero, Lorenzo
A1 Bañares Cañizares, Rafael
A2 , 
AB Background: There are no accurate tools to predict short-term mortality or the need for early retransplantation after liver transplantation (LT). A noninvasive measurement of indocyanine green clearance, the plasma disappearance rate (PDR), has been associated with initial graft function.Methods: We evaluated the ability of PDR to predict early mortality or retransplantation after LT. In this observational prospective study, 332 LT were analyzed. Donor, recipient, and intraoperative data were investigated. The ensuing score was prospectively evaluated in a validation cohort of 77 patients.Results: Thirty-three patients reached the main endpoint. By multivariate analysis, the only independent predictors of the endpoint were PDR (odds ratio [OR], 0.85; 95% confidence interval, 0.79-0.92) and international normalized ratio (OR, 1.45; 95% confidence interval, 1.17-1.82). A risk score weighted by the OR was built using cutoff values of 2.2 or greater for international normalized ratio (1 point) and less than 10%/min for PDR (2 points). Four categories (0 to 3) were possible. The risk of early death or retransplantation was associated with the score (0, 4.4%; 1, 6.5%; 2, 12%; and 3, 50%; χ for trend, P < 0.001). The score was also associated with duration of mechanical ventilation and intensive care unit stay. The score had a good diagnostic performance in the validation cohort (sensitivity, 60%; specificity, 95.5%; positive predictive value, 66.7%; negative predictive value, 94.1%).Conclusions: A simple score obtained within the first day after LT predicts short-term survival and need for retransplantation and may prove useful when selecting diagnostic and therapeutic strategies.
PB Lippincott, Williams & Wilkins
SN 0041-1337
YR 2016
FD 2016-03
LK https://hdl.handle.net/20.500.14352/110560
UL https://hdl.handle.net/20.500.14352/110560
LA eng
NO Olmedilla, Luis MD, PhD; Lisbona, Cristina J. MD; Pérez-Peña, José M. MD, PhD; López-Baena, José A. MD, PhD; Garutti, Ignacio MD, PhD; Salcedo, Magdalena MD, PhD; Sanz, Javier MD, PhD; Tisner, Manuel MD, PhD; Asencio, José M. MD, PhD; Fernández-Quero, Lorenzo MD, PhD; Bañares, Rafael MD, PhD. Early Measurement of Indocyanine Green Clearance Accurately Predicts Short-Term Outcomes After Liver Transplantation. Transplantation 100(3):p 613-620, March 2016. | DOI: 10.1097/TP.0000000000000980
NO 
DS Docta Complutense
RD 6 abr 2025