RT Journal Article
T1 Adhesive antibacterial coatings based on copolymers bearing thiazolium cationic groups and catechol moieties as robust anchors
A1 Chiloeches, Alberto
A1 Echeverría, Coro
A1 Cuervo Rodríguez, María Rocío
A1 Plachà, Daniela
A1 López-Fabal, Fátima
A1 Fernández-García, Marta
A1 Muñoz-Bonilla, Alexandra
AB Herein, we describe a simple approach for the preparation of antibacterial polymeric coatings based on mussel inspired catechol chemistry. A series of statistical copolymers composed of 2-(4-methylthiazol-5-yl)ethyl methacrylate (MTA) and N-(3,4-dihydroxyphenethyl) methacrylamide (DOMA) were synthesized by conventional free radical and reversible addition fragmentation chain transfer (RAFT) polymerizations. Subsequently, the thiazole groups of MTA units were quaternized with methyl and butyl iodide as alkylating agents to provide cationic copolymers with also adhesive anchoring groups of catechol. The copolymers were systematically studied to investigate the effects of composition (MTA/DOMA ratio), molecular weight and alkylating agent on adhesive and antibacterial properties. It was proved that DOMA units play a major role in the adhesion, while the antibacterial activity only decreases slightly with content of DOMA up to 32%. Remarkable, for similar MTA molar equivalent, the copolymers with higher molecular weight exhibit better antimicrobial properties in solution, whereas when they are tethered onto a surface as a coating, the copolymers with lower molecular weight showed enhanced antibacterial performance even against Gram-negative bacteria. These findings confirm that antimicrobial polymers attached onto surfaces behave in a different manner than in solution, and can be more effective as the mobility and accessibility of the cationic groups increase.
PB Elsevier
SN 0300-9440
YR 2019
FD 2019
LK https://hdl.handle.net/20.500.14352/101811
UL https://hdl.handle.net/20.500.14352/101811
LA eng
NO A. Chiloeches, C. Echeverría, R. Cuervo-Rodríguez, D. Plachà, F. López-Fabal, M. Fernández-García, A. Muñoz-Bonilla. Adhesive antibacterial coatings based on copolymers bearing thiazolium cationic groups and catechol moieties as robust anchors. Progress in Organic Coatings 2019 Sept 18; 136: 105272-105279
NO Ministerio de Economía y Competitividad (España)
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO European Commission
NO Consejo Superior de Investigaciones Científicas
DS Docta Complutense
RD 14 dic 2025