RT Journal Article
T1 Novel Insect Antifeedant and Ixodicidal Nootkatone Derivatives
A1 Galisteo Pretel, Alberto
A1 Pérez del Pulgar, Helena
A1 Olmeda García, Ángeles Sonia
A1 Gonzalez-Coloma, Azucena
A1 Barrero, Alejandro F.
A1 Quílez del Moral, José Francisco
AB Naturally occurring nootkatone, with reported insecticidal and acaricidal properties, has been used as a lead to generate molecular diversity and, consequently, new insect antifeedant and ixodicidal compounds. A total of 22 derivatives were generated by subjecting this molecule to several reactions including dehydrogenation with the iodine/DMSO system, oxidation with SeO2, epoxidation with mCPBA, oxidation or carbon homologations of the α-carbonyl position with TMSOTf (trimethylsilyl trifluoromethanesulfonate) followed by Rubottom and Dess Martin periodane oxidations, condensation with formaldehyde using Yb(OTf)3 as catalyst and dehydroxilation using the Grieco protocol. The insect antifeedant (against Myzus persicae and Ropaloshysum padi) and ixodicidal (against the tick Hyalomma lusitanicum) activities of these compounds were tested. Compound 20 was the most active substance against M. persicae and R. padi, and twice more efficient than nootkatone in the antitick test.
PB MDPI
SN 2218-273X
YR 2019
FD 2019-11-16
LK https://hdl.handle.net/20.500.14352/7927
UL https://hdl.handle.net/20.500.14352/7927
LA eng
NO Ministerio de Economía y Competitividad (MINECO)/FEDER
DS Docta Complutense
RD 6 abr 2025