RT Journal Article
T1 Artificial Tears: Biological Role of Their Ingredients in the Management of Dry Eye Disease
A1 Labetoulle, Marc
A1 Benítez Del Castillo Sánchez, José Manuel
A1 Barabino, Stefano
A1 Herrero Vanrell, María Del Rocío
A1 Daull, Philippe
A1 Garrigue, Jean Sebastien
A1 Rolando, Maurizio
AB Dry eye disease (DED) is the most common ocular surface disease, characterized by insufficient production and/or instability of the tear film. Tear substitutes are usually the first line of treatment for patients with DED. Despite the large variety of tear substitutes available on the market, few studies have been performed to compare their performance. There is a need to better understand the specific mechanical and pharmacological roles of each ingredient composing the different formulations. In this review, we describe the main categories of ingredients composing tear substitutes (e.g., viscosity-enhancing agents, electrolytes, osmo-protectants, antioxidants, lipids, surfactants and preservatives) as well as their effects on the ocular surface, and we provide insight into how certain components of tear substitutes may promote corneal wound healing, and/or counteract inflammation. Based on these considerations, we propose an approach to select the most appropriate tear substitute formulations according to the predominant etiological causes of DED.
PB MPDI
SN 1422-0067
YR 2022
FD 2022-02-23
LK https://hdl.handle.net/20.500.14352/72501
UL https://hdl.handle.net/20.500.14352/72501
LA eng
DS Docta Complutense
RD 8 abr 2025