%0 Journal Article
%A Fuso, Paola
%A Di Salvatore, Mariantonietta
%A Santonocito, Concetta
%A Guarino, Donatella
%A Autilio, Chiara
%A Mulè, Antonino
%A Arciuolo, Damiano
%A Rinninella, Antonina
%A Mignone, Flavio
%A Ramundo, Matteo
%A Di Stefano, Brunella
%A Orlandi, Armando
%A Capoluongo, Ettore
%A Nicolotti, Nicola
%A Franceschini, Gianluca
%A Martín Sánchez, Alejandro
%A Tortora, Giampaolo
%A Scambia, Giovanni
%A Barone, Carlo
%A Cassano, Alessandra
%T Let-7a-5p, miR-100-5p, miR-101-3p, and miR-199a-3p Hyperexpression as Potential Predictive Biomarkers in Early Breast Cancer Patients
%D 2021
%@ 2075-4426
%U https://hdl.handle.net/20.500.14352/4934
%X Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC).Patients and methods: We retrospectively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next-Generation-Sequencing (NGS) system.Results: Event-free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let-7a-5p (EFS p = 0.006; OS p = 0.0001), mirR-100-5p (EFS s p = 0.01; OS p = 0.03), miR-101-3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let-7a-5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up-regulation of the above miRNAs could represent biomarkers in breast cancer.
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