RT Journal Article
T1 Let-7a-5p, miR-100-5p, miR-101-3p, and miR-199a-3p Hyperexpression as Potential Predictive Biomarkers in Early Breast Cancer Patients
A1 Fuso, Paola
A1 Di Salvatore, Mariantonietta
A1 Santonocito, Concetta
A1 Guarino, Donatella
A1 Autilio, Chiara
A1 Mulè, Antonino
A1 Arciuolo, Damiano
A1 Rinninella, Antonina
A1 Mignone, Flavio
A1 Ramundo, Matteo
A1 Di Stefano, Brunella
A1 Orlandi, Armando
A1 Capoluongo, Ettore
A1 Nicolotti, Nicola
A1 Franceschini, Gianluca
A1 Martín Sánchez, Alejandro
A1 Tortora, Giampaolo
A1 Scambia, Giovanni
A1 Barone, Carlo
A1 Cassano, Alessandra
AB Background: The aim of this study is to identify miRNAs able to predict the outcomes in breast cancer patients after neoadjuvant chemotherapy (NAC).Patients and methods: We retrospectively analyzed 24 patients receiving NAC and not reaching pathologic complete response (pCR). miRNAs were analyzed using an Illumina Next-Generation-Sequencing (NGS) system.Results: Event-free survival (EFS) and overall survival (OS) were significantly higher in patients with up-regulation of let-7a-5p (EFS p = 0.006; OS p = 0.0001), mirR-100-5p (EFS s p = 0.01; OS p = 0.03), miR-101-3p (EFS p = 0.05; OS p = 0.01), and miR-199a-3p (EFS p = 0.02; OS p = 0.01) in post-NAC samples, independently from breast cancer subtypes. At multivariate analysis, only let-7a-5p was significantly associated with EFS (p = 0.009) and OS (p = 0.0008). Conclusion: Up-regulation of the above miRNAs could represent biomarkers in breast cancer.
PB MPDI
SN 2075-4426
YR 2021
FD 2021-08-20
LK https://hdl.handle.net/20.500.14352/4934
UL https://hdl.handle.net/20.500.14352/4934
LA eng
DS Docta Complutense
RD 8 abr 2025