RT Book, Section
T1 Role of Nutrient and Energy Sensors in the Development of Type 2 Diabetes
A1 Hurtado Carneiro, Verónica
A1 Pérez García, Ana
A1 Álvarez García, Elvira
A1 Sanz Miguel, María Del Carmen
A2 Anca Pantea Stoian, 
AB Cell survival depends on the constant challenge to match energy demands with nutrient availability. This process is mediated through a highly conserved network of metabolic fuel sensors that orchestrate both a cellular and whole-body energy balance. A mismatch between cellular energy demand and nutrient availability is a key factor in the development of type 2 diabetes, obesity, metabolic syndrome, and other associated pathologies; thus, understanding the fundamental mechanisms by which cells detect nutrient availability and energy demand may lead to the development of new treatments. This chapter reviews the role of the sensor PASK (protein kinase with PAS domain), analyzing its role in the mechanisms of adaptation to nutrient availability and the metabolic response in different organs (liver, hypothalamus) actively cooperating to control food intake, maintain glycaemia homeostasis, and prevent insulin resistance and weight gain.
PB IntechOpen
SN 9781838819033
SN 9781838819040
YR 2021
FD 2021-09-22
LK https://hdl.handle.net/20.500.14352/107985
UL https://hdl.handle.net/20.500.14352/107985
LA eng
NO Hurtado-Carneiro V, Pérez-García A, Álvarez E, et al. (2021) Role of Nutrient and Energy Sensors in the Development of Type 2 Diabetes. Type 2 Diabetes - From Pathophysiology to Cyber Systems. IntechOpen. Available at: http://dx.doi.org/10.5772/intechopen.95454.
DS Docta Complutense
RD 14 jun 2025