RT Journal Article
T1 Magnetic silica nanoparticle cellular uptake and cytotoxicity regulated by electrostatic polyelectrolytes DNA loading at their surface
A1 Davila-Ibanez, Ana
A1 Salgueirino, Veronica
A1 Martinez-Zorzano, Vicenta
A1 Marino-Fernández, Rosalía
A1 García-Lorenzo, Andrés
A1 Maceira-Campos, Melodie
A1 Muñoz Úbeda, Mónica
A1 Junquera González, María Elena
A1 Aicart Sospedra, Emilio
A1 Rivas, José
A1 Rodriguez-Berrocal, Javier
A1 Legido, Jose
AB Magnetic silica nanoparticles show great promise for drug delivery. The major advantages correspond to their magnetic nature and ease of biofunctionalization, which favors their ability to interact with cells and tissues. We have prepared magnetic silica nanoparticles with DNA fragments attached on their previously polyelectrolyte-primed surface. The remarkable feature of these materials is the compromise between the positive charges of the polyelectrolytes and the negative charges of the DNA. This dual-agent formulation dramatically changes the overall cytotoxicity and chemical degradation of the nanoparticles, revealing the key role that surface functionalization plays in regulating the mechanisms involved.
PB American Chemical Society
SN 1936-0851
YR 2011
FD 2011
LK https://hdl.handle.net/20.500.14352/92092
UL https://hdl.handle.net/20.500.14352/92092
LA eng
NO Davila-Ibanez AB, Salgueirino V, Martinez-Zorzano V, Mariño-Fernández R, García-Lorenzo A, Maceira-Campos M, Muñoz-Ubeda M, Junquera E, Aicart E, Rivas J, Rodriguez-Berrocal FJ, Legido JL. Magnetic silica nanoparticle cellular uptake and cytotoxicity regulated by electrostatic polyelectrolytes-DNA loading at their surface. ACS Nano. 2012 Jan 24;6(1):747-59. doi: 10.1021/nn204231g.
NO Ministerio de Ciencia e Innovación (España)
NO Xunta de Galicia
DS Docta Complutense
RD 6 abr 2025