RT Journal Article
T1 Understanding brain function in vascular cognitive impairment and dementia with EEG and MEG: A systematic review
A1 Torres Simón, Lucía
A1 Doval Moreno, Sandra
A1 Nebreda Pérez, Alberto
A1 Llinas, Sophia J.
A1 Marsh, Elisabeth B.
A1 Maestú Unturbe, Fernando
AB Vascular Cognitive Impairment (VCI) is the second most prevalent dementia after Alzheimer’s Disease (AD), and cerebrovascular disease (CBVD) is a major comorbid contributor to the progression of most neurodegenerative diseases. Early differentiation of cognitive impairment is critical given both the high prevalence of CBVD, and that its risk factors are modifiable. The ability for electroencephalogram (EEG) and magnetoencephalogram (MEG) to detect changes in brain functioning for other dementias suggests that they may also be promising biomarkers for early VCI. The present systematic review aims to summarize the literature regarding electrophysiological patterns of mild and major VCI. Despite considerable heterogeneity in clinical definition and electrophysiological methodology, common patterns exist when comparing patients with VCI to healthy controls (HC) and patients with AD, though there is a low specificity when comparing between VCI subgroups. Similar to other dementias, slowed frequency patterns and disrupted inter- and intra-hemispheric connectivity are repeatedly reported for VCI patients, as well as longer latencies and smaller amplitudes in evoked responses. Further study is needed to fully establish MEG and EEG as clinically useful biomarkers, including a clear definition of VCI and standardized methodology, allowing for comparison across groups and consolidation of multicenter efforts.
PB Elsevier Science Ltd
SN 2213-1582
YR 2022
FD 2022-05-10
LK https://hdl.handle.net/20.500.14352/71654
UL https://hdl.handle.net/20.500.14352/71654
LA eng
NO CRUE-CSIC (Acuerdos Transformativos 2022)
NO Universidad Complutense de Madrid/Banco de Santander
NO Ministerio de Ciencia e Innovación (MICINN)
DS Docta Complutense
RD 4 abr 2025