RT Journal Article
T1 The Endocannabinoid System Promotes Astroglial Differentiation by Acting on Neural Progenitor Cells
A1 Aguado Sánchez, Tania
A1 Palazuelos Diego, Javier
A1 Monory, Krisztina
A1 Stella, Nephi
A1 Cravatt, Benjamin
A1 Lutz, Beat
A1 Marsicano, Giovanni
A1 Kokaia, Zaal
A1 Guzmán Pastor, Manuel
A1 Galve Roperh, Ismael
AB Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival. The function of the endocannabinoid system has been extensively studied in differentiated neurons, but its potential role in neural progenitor cells remains to be elucidated. Here we show that the CB1 receptor and the endocannabinoid-inactivating enzyme fatty acid amide hydrolase are expressed, both in vitro and in vivo, in postnatal radial glia (RC2+ cells) and in adult nestin type I (nestin(+)GFAP+) neural progenitor cells. Cell culture experiments show that CB1 receptor activation increases progenitor proliferation and differentiation into astroglial cells in vitro. In vivo analysis evidences that, in postnatal CB1(-/-) mouse brain, progenitor proliferation and astrogliogenesis are impaired. Likewise, in adult CB1-deficient mice, neural progenitor proliferation is decreased but is increased in fatty acid amide hydrolase-deficient mice. In addition, endocannabinoid signaling controls neural progenitor differentiation in the adult brain by promoting astroglial differentiation of newly born cells. These results show a novel physiological role of endocannabinoids, which constitute a new family of signaling cues involved in the regulation of neural progenitor cell function.
PB Society for Neuroscience
SN 0270-6474
YR 2006
FD 2006
LK https://hdl.handle.net/20.500.14352/91163
UL https://hdl.handle.net/20.500.14352/91163
LA eng
NO Aguado, Tania, et al. «The Endocannabinoid System Promotes Astroglial Differentiation by Acting on Neural Progenitor Cells». The Journal of Neuroscience, vol. 26, n.o 5, febrero de 2006, pp. 1551-61. https://doi.org/10.1523/JNEUROSCI.3101-05.2006.
NO Ministerio de Educación y Ciencia (España)
NO Comunidad de Madrid
NO Fundación Científica de la Asociación Española Contra el Cáncer
NO German Research Foundation
NO National Institutes of Health
NO European Commission
NO Swedish Research Council
NO Swedish Foundation for Strategic Research
DS Docta Complutense
RD 5 abr 2025