RT Journal Article
T1 The immunity and redox clocks in mice, markers of lifespan
A1 Félix Escalera, Judith
A1 Martínez De Toda Cabeza, Irene
A1 Díaz Del Cerro, Estefanía
A1 Gil Agudo, Fernando
A1 Fuente Del Rey, María Mónica De La
AB Immune function and redox markers are used for estimating the aging rate, namely biological age (BA). However, it is unknown if this BA and its changes can be reflected in longevity. Thus, we must quantify BA in experimental animals. In peritoneal immune cells of 202 female mice (ICR/CD1) in different ages, 10 immune and 6 redox parameters were evaluated to construct two mathematical models for BA quantification in mice by multiple linear regression. Immune and redox parameters were selected as independent variables and chronological age as dependent, developing two models: the Immunity and the Redox Clocks, reaching both an adjusted R2 of 80.9% and a standard error of 6.38 and 8.57 weeks, respectively. Both models were validated in a different group of healthy mice obtaining a Pearson’s correlation coefficient of 0.844 and 0.800 (p < 0.001) between chronological and BA. Furthermore, they were applied to adult prematurely aging mice, which showed a higher BA than non-prematurely aging mice. Moreover, after positive and negative lifestyle interventions, mice showed a lower and higher BA, respectively, than their age-matched controls. In conclusion, the Immunity and Redox Clocks allow BA quantification in mice and both the ImmunolAge and RedoxAge in mice relate to lifespan.
PB Springer Nature
SN 2045-2322
YR 2024
FD 2024-01-19
LK https://hdl.handle.net/20.500.14352/119783
UL https://hdl.handle.net/20.500.14352/119783
LA eng
NO Félix, J., Martínez de Toda, I., Díaz-Del Cerro, E., Gil-Agudo, F., & De la Fuente, M. (2024). The immunity and redox clocks in mice, markers of lifespan. Scientific Reports, 14(1). https://doi.org/10.1038/S41598-024-51978-9
NO We would like to thank the Research Group UCM (910379), which funded this study. We would also like to thank Miguel Gueimonde's group for providing the probiotic Akkermansia mucciniphila and Teresa Requena's group for providing carrageenan. This research is part of the grants from the Spanish State Research Agency PID2019-106071RB-I00 (funded by MICIN/AEI/https://doi.org/10.13039/501100011033) and PID2022-136874OA-C32.
NO Universidad Complutense de Madrid
NO Ministerio de Ciencia e Innovación (España)
DS Docta Complutense
RD 19 dic 2025