RT Journal Article
T1 Common laboratory tests as indicators of COVID-19 severity on admission at high altitude: a single-center retrospective study in Quito (ECUADOR)
A1 Ballaz, Santiago J.
A1 Pulgar Sánchez, Mary
A1 Chamorro, Kevin
A1 Fernández Moreira, Esteban
A1 Ramírez, Hégira
A1 Mora, Francisco X.
A1 Fors, Martha
AB The current outbreak of SARS-Cov-2, a virus responsible for the coronavirus disease (namely COVID-19) in Wuhan (CHINA), has infected 107.1 million and caused over 2.34 million deaths worldwide (https://www.worldometers.info/coronavirus/). The main symptoms after infection are fever, dry cough, and fatigue, although disease severity can increase thereafter showing strong inter-individual differences. At worst, severe cases (4.7–6.1%) quickly progress to an acute respiratory distress syndrome (ARDS), septic shock, difficult-to-correct metabolic acidosis, coagulation dysfunction, and multiple organ failure. The fatality rate indeed reaches a 61.5% of the critically ill patients. In the fight against the coronavirus pandemic, prediction of disease severity is an urgent clinical need. COVID-19 prognosis largely relies on the clinical symptoms and computed tomography exams. In the hope to help risk-stratification and guide the timing of admission, some studies have also reported laboratory fluctuations in routine blood tests, which could become the mainstay for the forecasting of COVID-19 patients and the lessening of mortality [1]. Nevertheless, the characterization of the hematological and biochemical findings predicting COVID-19 severity are preliminary due to the low sample sizes, different proportions of severe patients, and geographic selection bias, and should therefore be taken with caution. Hematological biomarkers of COVID-19 severity requires validation by using larger samples of patients from different geographic localizations and ethnic groups across the globe.
PB De Gruyter
SN 1434-6621
YR 2021
FD 2021-03-05
LK https://hdl.handle.net/20.500.14352/124999
UL https://hdl.handle.net/20.500.14352/124999
LA eng
NO Ballaz, S., Pulgar-Sánchez, M., Chamorro, K., Fernández-Moreira, E., Ramírez, H., Mora, F. & Fors, M. (2021). Common laboratory tests as indicators of COVID-19 severity on admission at high altitude: a single-center retrospective study in Quito (ECUADOR). Clinical Chemistry and Laboratory Medicine (CCLM), 59(8), e326-e329. https://doi.org/10.1515/cclm-2021-0156
DS Docta Complutense
RD 19 dic 2025