RT Journal Article
T1 Prospective study of resting energy expenditure changes in head and neck cancer patients treated with chemoradiotherapy measured by indirect calorimetry
A1 García Peris, Pilar
A1 Lozano Barriuso, Miguel Ángel
A1 Velasco, Cristina
A1 de La Cuerda, Cristina
A1 Iriondo, Teresa
A1 Bretón Lesmes, Irene
A1 Camblor Álvarez, Miguel
A1 Navarro, Carlos
AB ObjectiveThe prevalence of malnutrition is high in patients with head and neck cancer due to tumor location and coadjuvant treatment. We studied changes in resting energy expenditure (REE) during treatment with chemoradiotherapy and compared the measured REE by indirect calorimetry (IC) with the value estimated by the Harris-Benedict (HB) formula.MethodsEighteen patients with head and neck cancer (15 men and 3 women, mean age 57 ± 10.7 y, age range 30–71 y) entered the study. All patients were treated with radiotherapy (70.8 ± 1 Gy, range 70–72) and received 37.4 ± 3.5 fractions (range 32–42) and concurrent chemotherapy with cisplatinum (absolute doses of 400 to 1000 mg). Nutrition assessment included anthropometry (body mass index, triceps skinfold thickness, subscapular skinfold thickness, midarm circumference, and midarm muscle circumference) and tetrapolar bioimpedance (Holtain BC). The IC (kcal/24 h; Deltatrac II MBM-200) was performed after an overnight fast. Measurements were done before treatment, at weeks 2, 4, and 6 of treatment, at the end of treatment, and 2 wk after treatment.ResultsBody mass index decreased during treatment from 24.7 ± 4.4 kg/m2 (range 16.9–31.4) to 22.3 ± 4.2 kg/m2 (range 15.1–29.6). REE (kcal/24 h) changed significantly during treatment (IC P < 0.05, HB formula P < 0.001). REE measured by IC appeared as a U-shaped curve, but REE estimated by the HB formula decreased during treatment. The HB underestimated REE measurements compared with IC. These differences were statistically significant before treatment, at the end of treatment, and 2 wk after treatment (P < 0.05) and showed a limited clinical agreement with the Bland-Altman method.ConclusionsREE measured by IC significantly changed during chemoradiotherapy. It was higher before treatment, at the end of treatment, and 2 wk after treatment. The HB formula underestimated REE in these patients. IC is a suitable method for measuring REE in this cohort of patients.
PB Elsevier
SN 0899-9007
YR 2005
FD 2005-11-06
LK https://hdl.handle.net/20.500.14352/108737
UL https://hdl.handle.net/20.500.14352/108737
LA eng
NO García-Peris, P., Lozano, M. A., Velasco, C., de La Cuerda, C., Iriondo, T., Bretón, I., Camblor, M., & Navarro, C. (2005). Prospective study of resting energy expenditure changes in head and neck cancer patients treated with chemoradiotherapy measured by indirect calorimetry. Nutrition (Burbank, Los Angeles County, Calif.), 21(11-12), 1107–1112. https://doi.org/10.1016/j.nut.2005.03.006
DS Docta Complutense
RD 29 abr 2025