RT Journal Article
T1 Speeding up heterogeneous catalysis with an improved highly reusable catalyst for the preparation of enantioenriched secondary alcohols
A1 Sánchez Carnerero, Esther M. Márquez
A1 Sandoval Torrientes, Rafael
A1 Urieta Mora, Javier
A1 Moreno Jiménez, Florencio
A1 Maroto, Beatriz Lora
A1 Moya Cerero, Santiago De La
AB A new catalytic heterogeneous system, very efficient and highly reusable, for the preparation of enantioenriched secondary alcohols through the addition of diethylzinc to benzaldehyde has been developed. This system is based on a chiral bis(hydroxyamide) ligand supported on crosslinked polystyrene. The catalyst has been shown to be very efficient, leading to the corresponding secondary alcohol with an enantiomeric excess of 93% in a time as short as 2 h and using just 4% of the heterogeneous catalyst and just 1.5 equivalents of the organozinc reagent. We have demonstrated that the new catalyst is very stable and can be efficiently recycled with no decrease in yield or enantioselectivity. The presented system has an unquestionable interest for the potential transfer of the reaction to the industry by using catalytic fluidized-bed reactors.
PB Elsevier
SN 1381-5148
YR 2017
FD 2017-04
LK https://hdl.handle.net/20.500.14352/18068
UL https://hdl.handle.net/20.500.14352/18068
LA eng
NO Received 29 November 2016, Revised 9 February 2017, Accepted 12 February 2017, Available online 14 February 2017.
NO Ministerio de Economía y Competitividad (MINECO)
DS Docta Complutense
RD 6 oct 2024