RT Journal Article
T1 Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4
A1 Valencia Mahón, Jaris
A1 Martínez Fernández De Sevilla, Lidia
A1 Fraile Ramos, Alberto
A1 Sacedón Ayuso, Rosa
A1 Jiménez Pérez, Eva
A1 Vicente López, Ángeles
A1 Varas Fajardo, Alberto
AB Dendritic cells and macrophages are common components of the tumour immune microenvironment and can contribute to immune suppression in both solid and haematological cancers. The Bone Morphogenetic Protein (BMP) pathway has been reported to be involved in cancer, and more recently in leukaemia development and progression. In the present study, we analyse whether acute lymphoblastic leukaemia (ALL) cells can affect the differentiation of dendritic cells and macrophages and the involvement of BMP pathway in the process. We show that ALL cells produce BMP4 and that conditioned media from ALL cells promote the generation of dendritic cells with immunosuppressive features and skew M1-like macrophage polarization towards a less pro-inflammatory phenotype. Likewise, BMP4 overexpression in ALL cells potentiates their ability to induce immunosuppressive dendritic cells and favours the generation of M2-like macrophages with pro-tumoral features. These results suggest that BMP4 is in part responsible for the alterations in dendritic cell and macrophage differentiation produced by ALL cells.
PB MDPI
SN 2073-4409
YR 2019
FD 2019-07-14
LK https://hdl.handle.net/20.500.14352/12563
UL https://hdl.handle.net/20.500.14352/12563
LA eng
NO Valencia Mahón, J., Martínez Fernández De Sevilla, L., Fraile Ramos, A. et al. «Acute Lymphoblastic Leukaemia Cells Impair Dendritic Cell and Macrophage Differentiation: Role of BMP4». Cells, vol. 8, n.o 7, julio de 2019, p. 722. DOI.org (Crossref), https://doi.org/10.3390/cells8070722.
NO Ministerio de Economía, Comercio y Empresa (España)
NO Instituto de Salud Carlos III
NO Comunidad de Madrid
NO Universidad Complutense de Madrid/Banco Santander
DS Docta Complutense
RD 17 abr 2025