RT Journal Article T1 The neuroprotective actions of oestradiol and oestrogenreceptors A1 Arévalo, María Ángeles A1 Azcoitia Elías, Iñigo A1 García Segura, Luis Miguel AB Hormones regulate homeostasis by communicating through the bloodstream to the body’s organs, including the brain. As homeostatic regulators of brain function, some hormones exert neuroprotective actions. This is the case for the ovarian hormone 17β‑oestradiol, which signals through oestrogen receptors (ERs) that are widely distributed in the male and female brain. Recent discoveries have shown that oestradiol is not only a reproductive hormone but also a brain-derived neuroprotective factor in males and females and that ERs coordinate multiple signalling mechanisms that protect the brain from neurodegenerative diseases, affective disorders and cognitive decline. PB Macmillan Publishers SN 1471-003X YR 2015 FD 2015-01 LK https://hdl.handle.net/20.500.14352/35412 UL https://hdl.handle.net/20.500.14352/35412 LA eng NO Ministerio de Economía y Competitividad (MINECO) DS Docta Complutense RD 8 abr 2025