RT Journal Article
T1 Relationship between 3p deletions and telomerase activity in non-small-cell lung cancer: prognostic implications
A1 Iniesta Serrano, María Pilar
A1 González-Quevedo, Rosa
A1 Morán, Alberto
A1 García-Aranda, Cristina
A1 Juan Chocano, María Del Carmen De
A1 Sánchez Pernaute, Andrés
A1 Torres García, Antonio José
A1 Díaz-Rubio García, Eduardo
A1 Balibrea Cantero, José Luis
A1 M Benito, 
AB 3p deletions and telomerase reactivation are two of the most frequent events described in relation to non-small-cell lung cancer (NSCLC) pathogenesis. Moreover, a number of genes that map on 3p have been proposed as candidates to tumour-suppressor genes of importance in the lung cancer process. In this work, we analysed deletions at different 3p foci in relationship to telomerase activity in 66 NSCLCs obtained from patients who had suffered potentially curative surgery. Also, we evaluated prognostic implications. DNA samples were analysed for 3p deletions using five different polymorphic human dinucleotide repeat DNA markers (D3S1619 at 3p22.2, D3S3623 at 3p22.1, D3S1260 at 3p21.33, D3S3697 at 3p14.3, and D3S3722 at 3p21.2). Telomerase activity was investigated by a TRAP-based method. Possible correlations between the different molecular markers and distributions of disease-free survival were estimated. Our data revealed a significant correlation between telomerase activity and losses of heterozygosity (LOH) on D3S3697 (P = 0.040), since all of the tumours showing deletion at this locus were positives for telomerase. Moreover, our results revealed clear associations with poor prognosis of patients, in the case of LOH at D3S1260 and D3S3697 (P = 0.005 and 0.005, respectively). According to our data, potential repressors for telomerase may be located in chromosome 3p. (C) 2004 Cancer Research UK.
PB SPRINGER NATURE
SN 0007-0920
YR 2004
FD 2004
LK https://hdl.handle.net/20.500.14352/116866
UL https://hdl.handle.net/20.500.14352/116866
LA eng
NO Iniesta P, González-Quevedo R, Morán A, García-Aranda C, de Juan C, Sánchez-Pernaute A, Torres A, Díaz-Rubio E, Balibrea JL, Benito M. Relationship between 3p deletions and telomerase activity in non-small-cell lung cancer: prognostic implications. Br J Cancer. 2004 May 17;90(10):1983-8. doi: 10.1038/sj.bjc.6601775. PMID: 15138482; PMCID: PMC2409473.
NO Sanofy Synthelabo
NO Bristol-Myers Squibb
NO Aventis Pharma
NO Red Respira C03/11
NO Red temática de investigación cooperativa de centros de cáncer C03/ 010, and FIS PI020193
DS Docta Complutense
RD 26 abr 2025