RT Journal Article
T1 Impact of a perioperative protocol for Parkinson's disease patients on use of contraindicated drugs
A1 Salgado Cámara, Paula
A1 De la Casa-Fages, Beatriz
A1 Sanchez-Soblechero, Alberto
A1 Mateo Sierra, Olga
A1 Martín Barbero, M Luisa
A1 Grandas Pérez, Francisco Javier
AB IntroductionDuring surgical admissions, the use of antidopaminergic drugs is associated with increased morbimortality and hospital stay in patients with Parkinson&apos;s disease (PD) and other parkinsonisms. We implemented a protocol to ensure adequate perioperative pharmacological management in our center, including educational sessions and complementary tools, such as an electronic Pharmacological Alert and a Patient Information Sheet.ObjectiveThe objective of this study was to analyze the changes in the prescription of contraindicated medications to PD or parkinsonism patients admitted for surgery, in the three years following implementation of the protocol, and to establish the compliance with the protocol among the medical staff involved in their hospital care over the same period.MethodsThis is an observational, analytical, prospective study with a before–after design.ResultsPrescription of contraindicated drugs decreased significantly over the study period (from 57.8% to 20.6%; p<0.001). Patients without an activated Pharmacological Alert had a 13.31 times higher risk of being prescribed contraindicated drugs than patients with such an alert (p<0.001). Neurologists and neurosurgeons used the protocol tools more than Emergency Department surgeons. There was very high compliance with the protocol in admissions for deep brain stimulation and related surgeries.ConclusionsThe protocol reduced the prescription of contraindicated drugs to PD and parkinsonism patients during their surgical admissions in our center. The Pharmacological Alert and Neurology clinics played a crucial role
PB Elsevier
SN 1578-1968
YR 2025
FD 2025
LK https://hdl.handle.net/20.500.14352/128227
UL https://hdl.handle.net/20.500.14352/128227
LA eng
NO P. Salgado-Cámara, B. De la Casa-Fages, A. Sánchez-Soblechero et al., Impact of a perioperative protocol for Parkinson’s disease patients on use of contraindicated drugs, Neurología, https://doi.org/10.1016/j.nrl.2023.11.011
NO The Movement Disorders Study Group of the Madrid Association of Neurology supported this work [Research Grant, 2017]
DS Docta Complutense
RD 20 ene 2026