TY  - JOUR
AU  - Compte, Marta
AU  - Harwood, Seandean L.
AU  - Martínez-Torrecuadrada, Jorge
AU  - Pérez-Chacón, Gema
AU  - González-García, Patricia
AU  - Tapia-Galisteo, Antonio
AU  - Bergen en Henegouwen, Paul M. P. Van
AU  - Sánchez Muñoz, Aranzazu
AU  - Fabregat, Isabel
AU  - Sanz, Laura
AU  - Zapata, Juan M.
AU  - Álvarez-Vallina, Luis
AU  - Palazon, Asis
PY  - 2021
DO  - 10.3389/fimmu.2020.614363
SN  - 1664-3224
UR  - https://hdl.handle.net/20.500.14352/107126
T2  - Frontiers in Immunology
AB  - Agonistic monoclonal antibodies (mAbs) targeting the co-stimulatory receptor 4-1BB are among the most effective immunotherapeutic agents across pre-clinical cancer models. However, clinical development of full-length 4-1BB agonistic mAbs, has been...
LA  - eng
KW  - Cancer immunotherapy
KW  - immunostimulatory antibodies
KW  - 4-1BB agonists
KW  - hepatotoxicity
KW  - trimerbodies
KW  - EGFR
KW  - EGFR-targeted 4-1BB agonists
TI  - Case Report: An EGFR-Targeted 4-1BB-agonistic Trimerbody Does Not Induce Hepatotoxicity in Transgenic Mice With Liver Expression of Human EGFR
TY  - journal article
VL  - 11
ER  -