RT Journal Article T1 Assessing Opportunities of SYCL for Biological Sequence Alignment on GPU-based Systems A1 Costanzo, Manuel A1 Rucci, Enzo A1 Naiouf, Marcelo A1 García Sánchez, Carlos A1 Prieto Matías, Manuel AB Bioinformatics and Computational Biology are two fields that have been exploiting GPUs for more than two decades, with being CUDA the most used programming language for them. However, as CUDA is an NVIDIA proprietarylanguage, it implies a strong portability restriction to a wide range of heterogeneous architectures, like AMD or Intel GPUs. To face this issue, the Khronos Group has recently proposed the SYCL standard, which is an open, royalty-free,cross-platform abstraction layer, that enables the programming of a heterogeneous system to be written using standard, single-source C++ code. Over the past few years, several implementations of this SYCL standard have emerged,being oneAPI the one from Intel. This paper presents the migration process of the SW# suite, a biological sequence alignment tool developed in CUDA, to SYCL using Intel’s oneAPI ecosystem. The experimental results show thatSW# was completely migrated with a small programmer intervention in terms of hand-coding. In addition, it was possible to port the migrated code between different architectures (considering multiple vendor GPUs and also CPUs), withno noticeable performance degradation on 5 different NVIDIA GPUs. Moreover, performance remained stable when switching to another SYCL implementation. As a consequence, SYCL and its implementations can offer attractive opportunities for the Bioinformatics community, especially considering the vast existence of CUDA-based legacy codes. YR 2024 FD 2024-02-19 LK https://hdl.handle.net/20.500.14352/113792 UL https://hdl.handle.net/20.500.14352/113792 LA eng DS Docta Complutense RD 9 abr 2025