RT Journal Article
T1 The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling
A1 Bosque, Alberto
A1 Aguiló, Juan Ignacio
A1 Alava, M. Angeles
A1 Naval, Javier
A1 Anel, Alberto
A1 Paz Artal, Estela Natividad
A1 Allende Martínez, Luis Miguel
AB The BH3-only protein Bim is required for maintaining the homeostasis of the immune system, since Bim regulates the down-modulation of T-cell responses, mainly through cytokine deprivation. Using T-cell blasts from healthy donors and also from patients with autoimmune lymphoproliferative syndromes (ALPSs) due to homozygous loss-of-function mutation of FasL (ALPS-Ic) or heterozygous mutation in the Fas/CD95 death domain (ALPS-Ia), it is shown that the induction of Bim expression during the process of human T-cell blast generation is strictly dependent on FasL/Fas-mediated signaling. The main pathway by which Fas signaling regulates the levels of Bim expression in human T-cell blasts is the death-domain- and caspase-independent generation of discrete levels of H2O2, which results in the net increase of Foxo3a levels. The present results connect the 2 main pathways described until the moment for the control of T-cell responses: death receptor-mediated activation-induced cell death and apoptosis by cytokine deprivation.
PB American Society of Hematology
SN 0006-4971
SN 1528-0020
YR 2006
FD 2006-10-24
LK https://hdl.handle.net/20.500.14352/98440
UL https://hdl.handle.net/20.500.14352/98440
LA eng
NO Bosque A, Aguiló JI, Alava MA, Paz-Artal E, Naval J, Allende LM, Anel A. The induction of Bim expression in human T-cell blasts is dependent on nonapoptotic Fas/CD95 signaling. Blood. 2007 Feb 15;109(4):1627-35. doi: 10.1182/blood-2006-05-022319. Epub 2006 Oct 24. PMID: 17062728.
DS Docta Complutense
RD 16 dic 2025