RT Journal Article
T1 One-Pot Multicomponent Synthesis of Methoxybenzo[h]quinoline-3-carbonitrile Derivatives; Anti-Chagas, X-ray, and In Silico ADME/Tox Profiling Studies
A1 Ramírez, Hegira
A1 Charris, Katiuska
A1 Fernández Moreira, Esteban
A1 Nogueda Torres, Benjamín
A1 Capparelli, Mario V.
A1 Ángel, Jorge
A1 Charris, Jaime
AB Several methoxybenzo[h]quinoline-3-carbonitrile analogs were designed and synthesized in a repositioning approach to developing compounds with anti-prostate cancer and anti-Chagas disease properties. The compounds were synthesized through a sequential multicomponent reaction of aromatic aldehydes, malononitrile, and 1-tetralone in the presence of ammonium acetate and acetic acid (catalytic). The effect of the one-pot method on the generation of the target product has been studied. The compounds were in vitro screened against bloodstream trypomastigotes of T. cruzi (NINOA and INC-5 strains) and were most effective at showing a better activity profile than nifurtimox and benznidazole (reference drugs). A study in silico on absorption, distribution, metabolism, excretion, and toxicity (ADME/Tox) profiling to help describe the molecular properties related to the pharmacokinetic aspects in the human body of these compounds was reported. In addition, X-ray data for the compound 2-Amino-5,6-dihydro-4-(3-hydroxy-4-methoxy-phenyl)-8-methoxybenzo[h]quinoline-3-carbonitrile 6 was being reported. Spectral (IR, NMR, and elemental analyses) data on all final compounds were consistent with the proposed structures.
PB MDPI
SN 1420-3049
YR 2021
FD 2021-11-19
LK https://hdl.handle.net/20.500.14352/125084
UL https://hdl.handle.net/20.500.14352/125084
LA eng
NO Ramírez, H., Charris, K., Fernandez-Moreira, E., Nogueda-Torres, B., Capparelli, M. V., Ángel, J., & Charris, J. (2021). One-Pot Multicomponent Synthesis of Methoxybenzo[h]quinoline-3-carbonitrile Derivatives; Anti-Chagas, X-ray, and In Silico ADME/Tox Profiling Studies. Molecules, 26(22), 6977. https://doi.org/10.3390/molecules26226977
DS Docta Complutense
RD 26 ene 2026