RT Journal Article
T1 Aerobic Exercise and Neuropathic Pain: Insights from Animal Models and Implications for Human Therapy
A1 Ruimonte Crespo, Jorge
A1 Plaza Manzano, Gustavo
A1 Díaz Arribas, María José
A1 Navarro Santana, Marcos José
A1 López Marcos, José Javier
A1 Fabero Garrido, Raúl
A1 Seijas Fernández, Tamara
A1 Valera Calero, Juan Antonio
AB This narrative review explores the complex relationship between aerobic exercise (AE) and neuropathic pain (NP), particularly focusing on peripheral neuropathies of mechanical origin. Pain, a multifaceted phenomenon, significantly impacts functionality and distress. The International Association for the Study of Pain’s definition highlights pain’s biopsychosocial nature, emphasizing the importance of patient articulation. Neuropathic pain, arising from various underlying processes, presents unique challenges in diagnosis and treatment. Our methodology involved a comprehensive literature search in the PubMed and SCOPUS databases, focusing on studies relating AE to NP, specifically in peripheral neuropathies caused by mechanical forces. The search yielded 28 articles and 1 book, primarily animal model studies, providing insights into the efficacy of AE in NP management. Results from animal models demonstrate that AE, particularly in forms like no-incline treadmill and swimming, effectively reduces mechanical allodynia and thermal hypersensitivity associated with NP. AE influences neurophysiological mechanisms underlying NP, modulating neurotrophins, cytokines, and glial cell activity. These findings suggest AE’s potential in attenuating neurophysiological alterations in NP. However, human model studies are scarce, limiting the direct extrapolation of these findings to human neuropathic conditions. The few available studies indicate AE’s potential benefits in peripheral NP, but a lack of specificity in these studies necessitates further research. In conclusion, while animal models show promising results regarding AE’s role in mitigating NP symptoms and influencing underlying neurophysiological mechanisms, more human-centric research is required. This review underscores the need for targeted clinical trials to fully understand and harness AE’s therapeutic potential in human neuropathic pain, especially of mechanical origin.
PB MDPI
SN 2227-9059
YR 2023
FD 2023-11-29
LK https://hdl.handle.net/20.500.14352/110721
UL https://hdl.handle.net/20.500.14352/110721
LA eng
NO Ruimonte-Crespo, J.; Plaza-Manzano, G.; Díaz-Arribas, M.J.; Navarro-Santana, M.J.; López-Marcos, J.J.; Fabero-Garrido, R.; Seijas-Fernández, T.; Valera-Calero, J.A. Aerobic Exercise and Neuropathic Pain: Insights from Animal Models and Implications for Human Therapy. Biomedicines 2023, 11, 3174. https://doi.org/10.3390/biomedicines11123174
NO 2023 Descuento MDPI
DS Docta Complutense
RD 7 abr 2025