RT Journal Article T1 Integrating T-cell epitope annotations with sequence and structural information using DAS A1 Diez Rivero, Carmen A1 García Boronat, María A1 Reche, Pedro A AB Immunoinformatics is an emerging new field that benefits from computational analyses and tools that facilitate the understanding of the immune system. A large number of immunoinformatics resources such as immune-related databases and analysis software are available through the World Wide Web for the benefit of the research community. However, immunoinformatics developments have sometimes remained isolated from mainstream bioinformatics. Therefore, there is clearly a need for integration, which will empower the exchange of data and annotations within the scientific community in a quick and efficient fashion. Here, we have chosen the Distributed Annotation System (DAS), for integrating in house annotations on experimental and predicted HLA I-restriction elements of CD8 T-cell epitopes with sequence and structural information. PB Biomedical Informatics Publishing Group SN 0973-2063 YR 2008 FD 2008 LK https://hdl.handle.net/20.500.14352/49419 UL https://hdl.handle.net/20.500.14352/49419 LA eng NO [01] M. N. Davies and D. R. Flower, Drug Discov. Today, 12: 389 (2007) [PMID: 17467575] [02] R. D. Dowell, R.M. et al., BMC Bioinformatics, 2: 7 (2001) [PMID: 11667947] [03] P. I. Olason, Nucleic Acids Res., 33: W468 (2005) [PMID: 15980514] [04] R. D. Finn et al., Bioinformatics 23: 1568 (2007) [PMID: 17850653] [05] C. H. Wu et al., Nucleic Acids Res., 34: D187 (2006) [PMID: 16381842] [06] P. A Reche et al., Bioinformatics, 21: 2140 (2005) [PMID: 15657103] [07] P. A Reche and E. L. Reinherz, Methods Mol. Biol., 409:185 (2007) [PMID: 18450001] [08] P. A Reche et al., Med. Immunol., 5: 1 (2006) [PMID: 16674822] [09] Prlic et al., Bioinformatics, 21: ii40 (2005) [PMID: 16204122] NO Ministerio de Educación y Ciencia NO Cancer Research Center (CNIO) DS Docta Complutense RD 28 abr 2024