RT Journal Article
T1 Tailoring the biological response of mesoporous bioactive materials
A1 Gómez Cerezo, María Natividad
A1 Izquierdo Barba, Isabel
A1 Arcos, Daniel
A1 Vallet Regí, María Dulce Nombre
AB Mesoporous bioactive glasses (MBGs) in the SiO2–CaO–P2O5 system have been prepared using different non-ionic structure directing agents (SDA): Brij58, F68, P123 and F127. For the first time, the bioactive response of MBGs can be tailored with the kind of SDA incorporated. This is because, in addition to the textural properties, we can use the SDA to tailor the local atomic environment within the MBG struts. These features lead to differences in the in vitro bioactive behaviour of MBGs. Among the different SDAs used in this work, the triblock copolymer F68 leads to MBGs that exhibit the fastest bioactivity and the fastest differentiation induction from a pre-osteoblast to an osteoblast phenotype. These results are explained in terms of a highly ordered mesoporous structure, more free calcium cations acting as silica network modifiers and small mesopores that avoid the formation of CaP nuclei within pores, which could obstruct the ionic exchange with the surrounding fluids.
PB Royal Society of Chemistry
SN 0959-9428
YR 2015
FD 2015-03-31
LK https://hdl.handle.net/20.500.14352/24051
UL https://hdl.handle.net/20.500.14352/24051
LA eng
NO Ministerio de Ciencia e Innovación
NO Ministerio de Economía y Competitividad
NO Agening Network of Excellence
DS Docta Complutense
RD 27 abr 2024