RT Journal Article
T1 Body mass index and all-cause mortality among type 2 diabetes mellitus patients: Findings from the 5-year follow-up of the MADIABETES cohort
A1 Salinero Fort, Miguel Ángel
A1 San Andrés Rebollo, Francisco Javier
A1 Gómez Campelo, Paloma
A1 De Burgos Lunar, Carmen
A1 Cárdenas Valladolid, Juan
A1 Abánades Herranz, Juan Carlos
A1 Otero Puime, Ángel
A1 Jiménez García, Rodrigo
A1 López De Andrés, Ana Isabel
A1 Miguel Yanes, José María De
AB PurposeTo analyse the association between body mass index (BMI) and all-cause mortality in a 5-year follow-up study with Spanish type 2 diabetes mellitus (T2DM) patients, seeking gender differences.Methods3443 T2DM outpatients were studied. At baseline and annually, patients were subjected to anamnesis, a physical examination, and biochemical tests. Data about demographic and clinical characteristics was also recorded, as was the treatment each patient had been prescribed. Mortality records were obtained from the Spanish National Institute of Statistics. Survival curves for BMI categories (Gehan-Wilcoxon test) and a multivariate Cox proportional hazard analysis were performed to identify adjusted Hazard Ratios (HRs) of mortality.ResultsMortality rate was 26.38 cases per 1000 patient-years (95% CI, 23.92–29.01), with higher rates in men (28.43 per 1000 patient-years; 95% CI, 24.87–32.36) than in women (24.31 per 1000 patient-years; 95% CI, 21.02–27.98) (p = 0.079). Mortality rates according to BMI categories were: 56.7 (95% CI, 40.8–76.6), 28.4 (95% CI, 22.9–34.9), 24.8 (95% CI, 21.5–28.5), 21 (95% CI, 16.3–26.6) and 23.7 (95% CI, 14.3–37) per 1000 person-years for participants with a BMI of < 23, 23–26.8, 26.9–33.1, 33.2–39.4, and > 39.4 kg/m2, respectively. The BMI values associated with the highest all-cause mortality were < 23 kg/m2, but only in males [HR: 2.78 (95% CI, 1.72–4.49; p < 0.001)], since in females this association was not significant [HR: 1.14 (95% CI, 0.64–2.04; p = 0.666)] (reference category for BMI: 23.0–26.8 kg/m2). Higher BMIs were not associated with higher mortality rates.ConclusionsIn an outpatient T2DM Mediterranean population sample, low BMI predicted all-cause mortality only in males.
PB Elsevier
YR 2017
FD 2017-09-01
LK https://hdl.handle.net/20.500.14352/92947
UL https://hdl.handle.net/20.500.14352/92947
LA eng
NO Salinero-Fort MA, San Andrés-Rebollo FJ, Gómez-Campelo P, de Burgos-Lunar C, Cárdenas-Valladolid J, Abánades-Herranz JC, Otero-Puime A, Jiménez-García R, López-de-Andrés A, de Miguel-Yanes JM; MADIABETES Research Group. Body mass index and all-cause mortality among type 2 diabetes mellitus patients: Findings from the 5-year follow-up of the MADIABETES cohort. Eur J Intern Med. 2017 Sep;43:46-52
NO Instituto de Salud Carlos III
NO Unión Europea
DS Docta Complutense
RD 12 abr 2025