RT Journal Article
T1 Spatiotemporal oscillatory patterns during working memory maintenance in mild cognitive impairment and subjective cognitive decline
A1 Serrano Martínez, Noelia
A1 López Sanz, David
A1 Bruña Fernández, Ricardo
A1 Garcés, Pilar
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Marcos Dolado, Alberto
A1 Prada Crespo, David
A1 Maestu Unturbe, Fernando
AB Working memory (WM) is a crucial cognitive process and its disruption is among the earliest symptoms of Alzheimer’s disease. While alterations of the neuronal processes underlying WM have been evidenced in mild cognitive impairment (MCI), scarce literature is available in subjective cognitive decline (SCD). We used magnetoencephalography during a WM task performed by MCI (n=45), SCD (n=49) and healthy elders (n=49) to examine group differences during the maintenance period (0–4000ms). Data were analyzed using time–frequency analysis and significant oscillatory differences were localized at the source level. Our results indicated significant differences between groups, mainly during the early maintenance (250–1250ms) in the theta, alpha and beta bands and in the late maintenance (2750–3750ms) in the theta band. MCI showed lower local synchronization in fronto-temporal cortical regions in the early theta–alpha window relative to controls (p=2×10−03) and SCD (p=4×10−03), and in the late theta window relative to controls (p=1×1003) and SCD (p=0.01). Early theta–alpha power was significantly correlated with memory scores (rho=0.24,p=0.02) and late theta power was correlated with task performance (rho=0.24,p=0.03) and functional activity scores (rho=−0.23,p=0.02). In the early beta window, MCI showed reduced power in temporo-posterior regions relative to controls (p=3×10−03) and SCD (p=0.02). Our results may suggest that these alterations would reflect that memory-related networks are damaged.
PB World Scientific Publishing
SN 0129-0657
YR 2019
FD 2019-09-16
LK https://hdl.handle.net/20.500.14352/100227
UL https://hdl.handle.net/20.500.14352/100227
LA eng
NO Serrano N, López-Sanz D, Bruña R, Garcés P, Rodríguez-Rojo IC, Marcos A, Crespo DP, Maestú F. Spatiotemporal Oscillatory Patterns During Working Memory Maintenance in Mild Cognitive Impairment and Subjective Cognitive Decline. Int J Neural Syst. 2020 Jan;30(1):1950019. doi: 10.1142/S0129065719500199. Epub 2019 Jun 19. PMID: 31522594.
NO Ministerio de Economía y Competitividad
DS Docta Complutense
RD 27 sept 2024