RT Journal Article
T1 Visual Outcomes of a Non-Diffractive Extended Depth-of-Focus Intraocular Lens in Patients with Early-Stage Age-Related Macular Degeneration
A1 Dorronzoro Ramirez, Emilio
A1 Sánchez Tena, Miguel Ángel
A1 Álvarez Peregrina, Cristina
A1 Cárdenas Rebollo, José Miguel
A1 Flores Cervantes, Dayan
A1 Sánchez Ramos, Celia
AB Background/Objectives: Age-related macular degeneration (AMD) is a leading cause of visual impairment in older adults and often coexists with cataracts. The indication of presbyopia-correcting intraocular lenses (IOLs) in these patients remains controversial. This study aimed to evaluate the clinical performance of a non-diffractive extended depth-of-focus (EDOF) IOL (LuxSmart™) compared to a monofocal plus IOL (Tecnis Eyhance™) in cataract patients with early-stage dry AMD. Methods: In this prospective observational study, 41 patients with early-stage AMD underwent bilateral cataract surgery with either LuxSmart™ or Tecnis Eyhance™ IOL implantation, targeting postoperative emmetropia. The eye selected for analysis was the first eye scheduled for surgery. Preoperative and postoperative evaluations included high and low-contrast distance visual acuity, intermediate and near visual acuity, defocus curves, ocular light scatter (halometry), and quality of life assessment (NEI VFQ-25). Postoperative biometric accuracy and refractive outcomes were also analyzed. Results: Both IOLs showed high refractive accuracy, with 100% of eyes within ±0.50 D of target. Postoperative uncorrected distance visual acuity was 0.10 ± 0.06 LogMAR for Eyhance and 0.07 ± 0.02 for LuxSmart (p = 0.06). Low contrast VA at 20% was 0.22 ± 0.11 (Eyhance) and 0.26 ± 0.16 (LuxSmart) (p = 0.49). Depth of focus was approximately 1.75 D for both lenses. Light scatter (LDI) improved postoperatively in both groups with no significant differences (p = 0.54). VFQ-25 scores showed improvement in daily activities, though no changes were observed in driving or mental health domains. Conclusions: Both lenses are safe and effective options for early AMD patients undergoing cataract surgery, providing good functional vision at multiple distances.
PB MDPI
YR 2025
FD 2025-08
LK https://hdl.handle.net/20.500.14352/124279
UL https://hdl.handle.net/20.500.14352/124279
LA eng
NO Dorronzoro-Ramirez E, Sanchez-Tena MA, Alvarez-Peregrina C, Cardenas Rebollo JM, Flores Cervantes D, Sánchez-Ramos C. Visual Outcomes of a Non-Diffractive Extended Depth-of-Focus Intraocular Lens in Patients with Early-Stage Age-Related Macular Degeneration. J Clin Med. 2025 Aug 23;14(17):5953. doi: 10.3390/jcm14175953. PMID: 40943713; PMCID: PMC12429355.
DS Docta Complutense
RD 31 dic 2025