RT Journal Article
T1 Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP.
A1 Soumelis, Vassili
A1 Kanzler, Holger
A1 Reche Gallardo, Pedro Antonio
A1 Yuan, Wei
A1 Edward, Gina
A1 Homey, Bernhart
A1 Gilliet, Michel
A1 Ho, Steve
A1 Antonenko, Svetlana
A1 Lauerma, Annti
A1 Smith, Kathleen
A1 Gorman, Daniel
A1 Zurawski, Sandra M.
A1 Abrams, Jon
A1 Menon, Satish
A1 McClanahan, Terri
A1 Waal-Malefyt, Rene de
A1 Bazan, Fernando
A1 Kastelein, Robert A.
A1 Liu, Yong-Jun
AB Whether epithelial cells play a role in triggering the immune cascade leading to T helper 2 (T(H)2)-type allergic inflammation is not known. We show here that human thymic stromal lymphopoietin (TSLP) potently activated CD11c(+) dendritic cells (DCs) and induced production of the T(H)2-attracting chemokines TARC (thymus and activation-regulated chemokine; also known as CCL17) and MDC (macrophage-derived chemokine; CCL22). TSLP-activated DCs primed naïve T(H) cells to produce the proallergic cytokines interleukin 4 (IL-4), IL-5, IL-13 and tumor necrosis factor-alpha, while down-regulating IL-10 and interferon-gamma. TSLP was highly expressed by epithelial cells, especially keratinocytes from patients with atopic dermatitis. TSLP expression was associated with Langerhans cell migration and activation in situ. These findings shed new light on the function of human TSLP and the role played by epithelial cells and DCs in initiating allergic inflammation.
PB Nature Publishing Group
SN 1529-2908
YR 2002
FD 2002
LK https://hdl.handle.net/20.500.14352/58247
UL https://hdl.handle.net/20.500.14352/58247
LA eng
DS Docta Complutense
RD 13 abr 2025