RT Journal Article
T1 Signaling, cancer cell plasticity, and intratumor heterogeneity
A1 Cordani, Marco
A1 Dando, Ilaria
A1 Ambrosini, Giulia
A1 González Menéndez, Pedro
AB Cancer’s complexity is in part due to the presence of intratumor heterogeneity and the dynamic nature of cancer cell plasticity, which create substantial obstacles in effective cancer management. Variability within a tumor arises from the existence of diverse populations of cancer cells, impacting the progression, spread, and resistance to treatments. At the core of this variability is the concept of cellular plasticity - the intrinsic ability of cancer cells to alter their molecular and cellular identity in reaction to environmental and genetic changes. This adaptability is a cornerstone of cancer’s persistence and progression, making it a formidable target for treatments. Emerging studies have emphasized the critical role of such plasticity in fostering tumor diversity, which in turn influences the course of the disease and the effectiveness of therapeutic strategies. The transformative nature of cancer involves a network of signal transduction pathways, notably those that drive the epithelial-to-mesenchymal transition and metabolic remodeling, shaping the evolutionary path of cancer cells. Despite advancements, our understanding of the precise molecular machinations and signaling networks driving these changes is still evolving, underscoring the necessity for further research. This editorial presents a series entitled “Signaling Cancer Cell Plasticity and Intratumor Heterogeneity” in Cell Communication and Signaling, dedicated to unraveling these complex processes and proposing new avenues for therapeutic intervention.
PB BMC
SN 1478-811X
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/118887
UL https://hdl.handle.net/20.500.14352/118887
LA eng
NO Cordani, M., Dando, I., Ambrosini, G. et al. Signaling, cancer cell plasticity, and intratumor heterogeneity. Cell Commun Signal 22, 255 (2024). https://doi.org/10.1186/s12964-024-01643-5
NO I.D. was supported by the Ministero dell’Istruzione, dell’Università e della Ricerca (MIUR); G.A. is funded thanks to a fellowship supported by the Fondazione Umberto Veronesi. P. G.-M. and M.C. are supported by grants RYC2021033856I and RYC2021-031003I, respectively, funded by MICIU/AEI/https://doi.org/10.13039/501100011033 and, by European Union NextGenerationEU/PRTR.
NO Ministero dell'Istruzione, dell'Università e della Ricerca
NO Fondazione Umberto Veronesi
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO European Commission
DS Docta Complutense
RD 11 abr 2025