RT Journal Article
T1 Nosocomial infections in adult patients supported by extracorporeal membrane oxygenation in a cardiac intensive care unit
A1 Mornese Pinna, Simone
A1 Sousa Casasnovas, Iago
A1 Olmedo, María
A1 Machado, Marina
A1 Juàrez Fernández, Miriam
A1 Devesa Cordero, Carolina
A1 Galar, Alicia
A1 Álvarez Uría, Ana
A1 Fernández Avilés, Francisco
A1 García Carreño, Jorge
A1 Martínez-Sellés D Oliveira Soares, Manuel
A1 De Rosa, Francesco Giuseppe
A1 Corcione, Silvia
A1 Bouza Santiago, Emilio
A1 Muñoz García, Patricia Carmen
A1 Valerio Minero, Maricela
AB The use of venoarterial (VA) extracorporeal membrane oxygenation therapy (ECMO) in patients admitted to cardiac intensive care units (CICU) has increased. Data regarding infections in this population are scarce. In this retrospective study, we analyzed the risk factors, outcome, and predictors of in-hospital mortality due to nosocomial infections in patients with ECMO admitted to a single coronary intensive care unit between July 2013 and March 2019 treated with VA-ECMO for >48 h. From 69 patients treated with VA-ECMO >48 h, (median age 58 years), 29 (42.0%) patients developed 34 episodes of infections with an infection rate of 0.92/1000 ECMO days. The most frequent were ventilator-associated pneumonia (57.6%), tracheobronchitis (9.1%), bloodstream infections (9.1%), skin and soft tissue infections (9.1%), and cytomegalovirus reactivation (9.1%). In-hospital mortality was 47.8%, but no association with nosocomial infections was found (p = 0.75). The number of days on ECMO (OR 1.14, 95% CI 1.01–1.30, p = 0.029) and noninfectious complications were higher in the infected patients (OR: 3.8 95% CI = 1.05–14.1). A higher baseline creatinine value (OR: 8.2 95% CI = 1.12–60.2) and higher blood lactate level at 4 h after ECMO initiation (OR: 2.0 95% CI = 1.23–3.29) were significant and independent risk factors for mortality. Conclusions: Nosocomial infections in medical patients treated with VA-ECMO are very frequent, mostly Gram-negative respiratory infections. Preventive measures could play an important role for these patients.
PB MDPI
YR 2023
FD 2023-04-20
LK https://hdl.handle.net/20.500.14352/104864
UL https://hdl.handle.net/20.500.14352/104864
LA eng
NO Mornese Pinna S, Sousa Casasnovas I, Olmedo M, Machado M, Juàrez Fernández M, Devesa-Cordero C, et al. Nosocomial Infections in Adult Patients Supported by Extracorporeal Membrane Oxygenation in a Cardiac Intensive Care Unit. Microorganisms. 2023;11(4):1079
NO 2023 Descuento MDPI
DS Docta Complutense
RD 23 dic 2025