RT Journal Article
T1 Design and sustainable synthesis of small mannose-based glycodendrons as ligands for HIV-1 envelope protein gp120: Toward an explanation for their binding
A1 Perona Requena, Almudena
A1 Ramírez López, Pedro
A1 Suárez Álvarez, José Ramón
A1 Hernáiz Gómez-Degano, María Josefa
A1 Martínez Espinosa, Carlos Antonio
A1 Merchán, Alejandro
AB On the basis of the interesting properties that glucuronic acid-based glycodendrimers and glycodendrons show  against Dengue virus through their interaction with its envelope protein, herein we describe the design, sustainable synthesis and anti HIV-1 evaluation of a series of mannose-based glycodendrimers bearing different scaffolds, valency and functional groups at the focal position. Their sustainable chemical synthesis was performed using microwave-assisted copper(I) catalyzed azide-alkyne cycloaddition (CuAAC) reaction to yield  glycoconjugates with full conversions (99%), allowing the reduction of the reaction time from 16 h to 60–120 min. Surface plasmon resonance studies have demonstrated that the small mannose-based glycodendrons  (divalent derivatives) give the best binding interactions with the HIV-1 gp120 envelope protein, being the most active those that have a methoxymethyl group or an azidomethyl group at the focal position. Molecular modeling studies were carried out to simulate and explain the binding observed by surface plasmon resonance. This work reports a sustainable synthesis of small mannose-based glycodendrons as novel and potent anti HIV lead compounds.
PB Elsevier
YR 2024
FD 2024
LK https://hdl.handle.net/20.500.14352/122854
UL https://hdl.handle.net/20.500.14352/122854
LA eng
NO Carlos Martínez, Alejandro Merchán, Almudena Perona, Pedro Ramírez-López, José Ramón Suárez, María J. Hernáiz, Design and sustainable synthesis of small mannose-based glycodendrons as ligands for HIV-1 envelope protein gp120: Toward an explanation for their binding, Catalysis Today, Volume 429, 2024, 114493,
NO The 1H NMR and 13C NMR spectra were carried out at CAI Unidad de Resonancia Magnética (UCM). The authors gratefully acknowledge financial support provided by the Spanish Ministerio de Ciencia e Innovacion, ´ Grants RTI2018-096037B-I00, TED2021-130430B-C21, and PDC2022-133817-I00.
NO Ministerio de Cienca e Innovación (España)
DS Docta Complutense
RD 9 abr 2026