RT Journal Article T1 Safety-First Framework for AI-Enabled Anamnesis in Head and Neck Surgery: Evidence Synthesis from a Narrative Review A1 Vaira, Luigi Angelo A1 Qadeer, Hareem A1 Lechien, Jerome R. A1 Maniaci, Antonino A1 Maglitto, Fabio A1 Troise, Stefania A1 Chiesa-Estomba, Carlos M. A1 Consorti, Giuseppe A1 Cirignaco, Giulio A1 Iannella, Giannicola A1 Navarro Cuéllar, Carlos A1 Salzano, Giovanni A1 Soro, Giovanni Maria A1 Boscolo Rizz, Paolo A1 Vellone, Valentino A1 Riu, Giacomo De AB Objectives: To synthesize evidence on artificial intelligence (AI)-enabled medical history taking (anamnesis)—beyond large language models (LLMs) alone—and to translate findings into implications and research priorities for head and neck surgery. Methods: We performed a PRISMA-informed narrative review. Searches from database inception to 31 December 2025 (updated 3 January 2026) were conducted in MEDLINE (PubMed), Embase, Scopus, Web of Science Core Collection, IEEE Xplore, and ACM Digital Library, supplemented by medRxiv/arXiv screening and citation chasing. We included studies evaluating or describing AI-supported history capture/summarization, conversational interviewing, symptom checker/digital triage, EHR-integrated intake-to-decision support pipelines, voice interviewing, education/training systems, and governance/ethical considerations related to digital anamnesis. Findings were synthesized by system category and by cross-cutting outcome domains, with a head and neck surgery interpretive lens. Results: Fifty studies (2014–2025) were included. Evidence most consistently suggested feasibility and acceptability of pre-consultation computer-assisted history taking and the potential to reduce documentation burden and improve structured capture. In contrast, symptom checkers and digital triage tools showed highly variable diagnostic/triage performance and prominent safety concerns, highlighting the importance of conservative red-flag escalation strategies, continuous monitoring, and clear accountability. LLM-based diagnostic dialogue demonstrated strong performance in controlled evaluations, but prospective real-world validation, governance, and workflow integration remain limited. Conclusions: AI-enabled anamnesis comprises heterogeneous tools with uneven evidence. For head and neck surgery, potential near-term applications may include structured pre-visit intake, clinician-facing summarization, and training applications, whereas autonomous triage warrants harm-oriented, specialty-calibrated validation and robust governance prior to broader clinical reliance. PB MDPI YR 2026 FD 2026-03-14 LK https://hdl.handle.net/20.500.14352/134159 UL https://hdl.handle.net/20.500.14352/134159 LA eng NO Vaira LA, Qadeer H, Lechien JR, Maniaci A, Maglitto F, Troise S, et al. Safety-First Framework for AI-Enabled Anamnesis in Head and Neck Surgery: Evidence Synthesis from a Narrative Review. JCM 2026;15:2218. https://doi.org/10.3390/jcm15062218. DS Docta Complutense RD 9 abr 2026