RT Journal Article
T1 The role of gut microbiota in cerebrovascular disease and related dementia
A1 Cuartero Desviat, María Isabel
A1 García Culebras, Alicia
A1 Nieto Vaquero, Carmen
A1 Fraga, Enrique
A1 Torres López, Cristina
A1 Pradillo Justo, Jesús Miguel
A1 Lizasoaín Hernández, Ignacio
A1 Moro Sánchez, María Ángeles
AB In recent years, increasing evidence suggests that commensal microbiota may play an important role not only in health but also in disease including cerebrovascular disease. Gut microbes impact physiology, at least in part, by metabolizing dietary factors and host-derived substrates and then generating active compounds including toxins. The purpose of this current review is to highlight the complex interplay between microbiota, their metabolites. and essential functions for human health, ranging from regulation of the metabolism and the immune system to modulation of brain development and function. We discuss the role of gut dysbiosis in cerebrovascular disease, specifically in acute and chronic stroke phases, and the possible implication of intestinal microbiota in post-stroke cognitive impairment and dementia, and we identify potential therapeutic opportunities of targeting microbiota in this context.
PB Wiley
SN 0007-1188
SN 1476-5381
YR 2023
FD 2023-07-12
LK https://hdl.handle.net/20.500.14352/103324
UL https://hdl.handle.net/20.500.14352/103324
LA eng
NO Cuartero MI, García-Culebras A, Nieto-Vaquero C, Fraga E, Torres-López C, Pradillo J, Lizasoain I, Moro MÁ. The role of gut microbiota in cerebrovascular disease and related dementia. Br J Pharmacol. 2024 Mar;181(6):816-839. doi: 10.1111/bph.16167. Epub 2023 Jul 12
DS Docta Complutense
RD 18 abr 2025