RT Journal Article
T1 BMP9 Promotes an Epithelial Phenotype and a Hepatocyte-like Gene Expression Profile in Adult Hepatic Progenitor Cells
A1 Addante, Annalisa
A1 González-Corralejo, Carlos
A1 Roncero Romero, Cesáreo
A1 Lazcanoiturburu, Nerea
A1 García-Sáez, Juan
A1 Herrera González, Blanca María
A1 Sánchez Muñoz, Aranzazu
AB Bone morphogenetic protein 9 (BMP9), a member of the TGF-β superfamily, has emerged as a new player in chronic liver diseases (CLDs). Its levels increase in the fibrotic liver where it promotes fibrogenesis. It also regulates hepatic progenitor cells (oval cells in rodents), a cell population that contributes to repopulate the liver and recover functionality upon severe damage, but it can also be pro-fibrogenic, depending upon the hepatic microenvironment. Here we analyze the effect of chronic exposure to BMP9 in oval cells. We show that cells chronically treated with BMP9 (B9T-OC) display a more epithelial and hepatocyte-like phenotype while acquiring proliferative and survival advantages. Since our previous studies had revealed a functional crosstalk between BMP9 and the HGF/c-Met signaling pathways in oval cells, we analyzed a possible role for HGF/c-Met in BMP9-induced long-term effects. Data evidence that active c-Met signaling is necessary to obtain maximum effects in terms of BMP9-triggered hepatocytic differentiation potential, further supporting functionally relevant cooperation between these pathways. In conclusion, our work reveals a novel action of BMP9 in liver cells and helps elucidate the mechanisms that serve to increase oval cell regenerative potential, which could be therapeutically modulated in CLD.
PB MDPI
SN 2073-4409
YR 2022
FD 2022-01-21
LK https://hdl.handle.net/20.500.14352/105272
UL https://hdl.handle.net/20.500.14352/105272
LA eng
NO Addante, A.; González-Corralejo, C.; Roncero, C.; Lazcanoiturburu, N.; García-Sáez, J.; Herrera, B.; Sánchez, A. BMP9 Promotes an Epithelial Phenotype and a Hepatocyte-like Gene Expression Profile in Adult Hepatic Progenitor Cells. Cells 2022, 11, 365.
NO Ministerio de Ciencia, Innovación y Universidades (España)
DS Docta Complutense
RD 9 abr 2025