RT Journal Article
T1 The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health
A1 De Frutos Lucas, Jaisalmer
A1 Cuesta Prieto, Pablo
A1 López Sanz, David
A1 Peral Suárez, África
A1 Cuadrado Soto, Esther
A1 Ramírez Toraño, Federico
A1 Brown, Belinda M.
A1 Serrano, Juan M.
A1 Laws, Simon M.
A1 Rodríguez Rojo, Inmaculada Concepción
A1 Verdejo Román, Juan
A1 Bruña Fernández, Ricardo
A1 Delgado Losada, María Luisa
A1 Barabash Bustelo, Ana
A1 López Sobaler, Ana María
A1 López Sánchez, Ramón
A1 Marcos Dolado, Alberto
A1 Maestu Unturbe, Fernando
AB Background: Neuronal hyperexcitability and hypersynchrony have been described as key features of neurophysiological dysfunctions in the Alzheimer’s disease (AD) continuum. Conversely, physical activity (PA) has been associated with improved brain health and reduced AD risk. However, there is controversy regarding whether AD genetic risk (in terms of APOE ε4 carriage) modulates these relationships. The utilization of multiple outcome measures within one sample may strengthen our understanding of this complex phenomenon. Method: The relationship between PA and functional connectivity (FC) was examined in a sample of 107 healthy older adults using magnetoencephalography. Additionally, we explored whether ε4 carriage modulates this association. The correlation between FC and brain structural integrity, cognition, and mood was also investigated. Results: A relationship between higher PA and decreased FC (hyposynchrony) in the left temporal lobe was observed among all individuals (across the whole sample, in ε4 carriers, and in ε4 non-carriers), but its effects manifest differently according to genetic risk. In ε4 carriers, we report an association between this region-specific FC profile and preserved brain structure (greater gray matter volumes and higher integrity of white matter tracts). In this group, decreased FC also correlated with reduced anxiety levels. In ε4 non-carriers, this profile is associated with improved cognition (working and episodic memory). Conclusions: PA could mitigate the increase in FC (hypersynchronization) that characterizes preclinical AD, being beneficial for all individuals, especially ε4 carriers.
PB BMC
SN 1758-9193
YR 2020
FD 2020-04-24
LK https://hdl.handle.net/20.500.14352/102194
UL https://hdl.handle.net/20.500.14352/102194
LA eng
NO de Frutos-Lucas, J., Cuesta, P., López-Sanz, D., Peral-Suárez, Á., Cuadrado-Soto, E., Ramírez-Toraño, F., Brown, B., Serrano, J. M., Laws, S. M., Rodríguez-Rojo, I. C., Verdejo-Román, J., Bruña, R., Delgado-Losada, M. L., Barabash, A., López-Sobaler, A. M., López-Higes, R., Marcos, A., & Maestú, F. (2020). The relationship between physical activity, apolipoprotein E ε4 carriage, and brain health. Alzheimer's Research & Therapy, 12, 1-12.
NO Ministerio de Economía y Competitividad
NO NEUROCENTRO
NO Fundación La Caixa
DS Docta Complutense
RD 7 abr 2025