RT Journal Article
T1 Chitosan derivatives-based films as pH-sensitive drug delivery systems with enhanced antioxidant and antibacterial properties
A1 Affes, Sawsan
A1 Aranaz Corral, Inmaculada
A1 Heras Caballero, Ángeles María
A1 Nasri, Moncef
A1 Maalej, Hana
A1 Acosta Contreras, Florentina Niuris
AB The purpose of this study was to develop and characterize chitosan (Ch)-based films incorporated with varying molecular weight (Mw) and acetylation degree (AD) chitosan-depolymerization-products (CDP), to be applied as drug delivery materials. As compared to Ch-film, optical and antioxidant potentials of Ch/CDP-based films were improved, particularly using low Mw and AD-CDP. Whereas, films water resistance, mechanical and antibacterial properties increased as CDP-Mw increased and AD decreased. For the thermal and swelling behaviors, better values were obtained using higher Mw and AD-CDP. Further, to assess their in vitro ciprofloxacin (CFX)- release behavior, loaded-CFX Ch/CDP-based films, crosslinked using glutaraldehyde, were prepared. Expect of elongation at break, crosslinked CFX-loaded films showed increased optical, water resistance, tensile strength and thermal properties, as compared to unloaded films. The CFX-release profiles indicated that a slower and sustained release was observed, particularly when using lower Mw and AD-CDP, and mainly for the crosslinked films during 48 h. These films can release CFX for up to 54% in 6 and 24 h, at pH 1.2 and 7.4, respectively. Through this study, novel biodegradable, swellable and pH-sensitive crosslinked Ch/CDP-based films may be considered as suitable and promising drug delivery systems.
SN 0141-8130
YR 2021
FD 2021-07
LK https://hdl.handle.net/20.500.14352/96406
UL https://hdl.handle.net/20.500.14352/96406
LA eng
NO Affes, Sawsan, et al. «Chitosan Derivatives-Based Films as pH-Sensitive Drug Delivery Systems with Enhanced Antioxidant and Antibacterial Properties». International Journal of Biological Macromolecules, vol. 182, julio de 2021, pp. 730-42. DOI.org (Crossref), https://doi.org/10.1016/j.ijbiomac.2021.04.014.
NO Ministry of Higher Education and Scientific Research (Tunisia)
NO Ministerio de Economía, Comercio y Empresa (España)
DS Docta Complutense
RD 5 abr 2025