%0 Journal Article
%A Martínez‐López, Angélica
%A García Casas, Ana
%A Infante, Guiomar
%A González‐Fernández, Mónica
%A Salvador, Nélida
%A Lorente, Mar
%A Mendiburu-Eliçabe Garganta, Marina
%A Gonzalez‐Moreno, Santiago 
%A Villarejo‐Campos, Pedro 
%A Malliri, Angeliki 
%A Lorente Pérez, María Del Mar
%A Velasco Díez, Guillermo
%A Castillo Lluva, Sonia
%T POTEE promotes breast cancer cell malignancy by inducing invadopodia formation through the activation of SUMOylated Rac1
%D 2023
%@ 1574-7891
%U https://hdl.handle.net/20.500.14352/100434
%X TThe small GTPase Rac1 (Ras-related C3 botulinum toxin substrate 1) has been implicated in cancer progression and in the poor prognosis of various types of tumors. Rac1 SUMOylation occurs during epithelial-mesenchymal transition (EMT), and it is required for tumor cell migration and invasion. Here we identify POTEE (POTE Ankyrin domain family member E) as a novel Rac1-SUMO1 effector involved in breast cancer malignancy that controls invadopodium formation through the activation of Rac1-SUMO1. POTEE activates Rac1 in the invadopodium by recruiting TRIO-GEF (triple functional domain protein), and it induces tumor cell proliferation and metastasis in vitro and in vivo. We found that the co-localization of POTEE with Rac1 is correlated with more aggressive breast cancer subtypes. Given its role in tumor dissemination, the leading cause of cancer-related deaths, POTEE could represent a potential therapeutic target for these types of cancer.
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