RT Journal Article
T1 The relationship between retinal layers and brain areas in asymptomatic first-degree relatives of sporadic forms of Alzheimer’s disease: an exploratory analysis
A1 López Cuenca, Inés
A1 Marcos Dolado, Alberto
A1 Yus Fuertes, Miguel
A1 García Martín, Elena Salobrar
A1 Elvira Hurtado, Lorena
A1 Fernández Albarral, José
A1 Salazar Corral, Juan José
A1 Ramírez Sebastián, Ana Isabel
A1 Sánchez-Puebla Fernández, Lidia
A1 Fuentes Ferrer, Manuel Enrique
A1 Barabash Bustelo, Ana
A1 Ramírez Toraño, Federico
A1 Gil Martínez, Lidia
A1 Arrazola García, Juan Lorenzo
A1 Gil Gregorio, Pedro
A1 Hoz Montañana, María Rosa De
A1 Ramírez Sebastián, José Manuel
AB Background: Two main genetic risks for sporadic Alzheimer’s disease (AD) are a family history and ɛ4 allele of apolipoprotein E. The brain and retina are part of the central nervous system and share pathophysiological mechanisms in AD.Methods: We performed a cross-sectional study with 30 participants without a family history of sporadic AD (FH−) and noncarriers of ApoE ɛ4 (ApoE ɛ4−) as a control group and 34 participants with a family history of sporadic AD (FH+) and carriers of at least one ɛ4 allele (ApoE ɛ4+). We analyzed the correlations between macular volumes of retinal layers and thickness of the peripapillary retinal nerve fiber layer (pRNFL) measured by optical coherence tomography (OCT) with the brain area parameters measured by magnetic resonance imaging (MRI) in participants at high genetic risk of developing AD (FH+ ApoE ɛ4+).Results: We observed a significant volume reduction in the FH+ ApoE ɛ4+ group compared with the control group in some macular areas of (i) macular RNFL (mRNFL), (ii) inner plexiform layer (IPL), (iii) inner nuclear layer (INL), and (iv) outer plexiform layer (OPL). Furthermore, in the FH+ ApoE ɛ4+ group, the retinal sectors that showed statistically significant volume decrease correlated with brain areas that are affected in the early stages of AD. In the same group, the peripapillary retinal nerve fiber layer (pRNFL) did not show statistically significant changes in thickness compared with the control group. However, correlations of these sectors with the brain areas involved in this disease were also found.Conclusions: In cognitively healthy participants at high genetic risk of developing sporadic forms of AD, there are significant correlations between retinal changes and brain areas closely related to AD such as the entorhinal cortex, the lingual gyrus, and the hippocampus.
PB BMC (Springer)
SN 1758-9193
YR 2022
FD 2022-06-04
LK https://hdl.handle.net/20.500.14352/71698
UL https://hdl.handle.net/20.500.14352/71698
LA eng
NO López Cuenca, I., Marcos Dolado, A., Yus Fuertes, M. et al. «The Relationship between Retinal Layers and Brain Areas in Asymptomatic First-Degree Relatives of Sporadic Forms of Alzheimer’s Disease: An Exploratory Analysis». Alzheimer’s Research & Therapy, vol. 14, n.o 1, diciembre de 2022, p. 79. DOI.org (Crossref), https://doi.org/10.1186/s13195-022-01008-5.
NO Ministerio de Ciencia, Innovación y Universidades (España)
NO Instituto de Salud Carlos III
NO Ministerio de Economía, Comercio y Empresa (España)
NO Universidad Complutense de Madrid
DS Docta Complutense
RD 10 abr 2025